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Brief Title: In Vitro Evaluation of Immune Responses in Cutaneous T-Cell Lymphoma (CTCL)
Official Title: In Vitro Evaluation of Immune Responses in CTCL
Study ID: NCT00177190
Brief Summary: This is an in vitro evaluation of cutaneous T-cell lymphoma using patients' blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/CD 8 cells.
Detailed Description: This is an in vitro evaluation of cutaneous T-cell lymphoma using patients blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/ CD 8 cells with the following objectives: * Objective I: Evaluate the feasibility of the preparation of dendritic cells (DCs), CD8 and Sezary cells (all CD4 positive) in vitro, obtained from the buffy coats or a skin biopsy from an area with tumor involvement of subjects with cutaneous t-cell lymphoma (CTCL) and Sezary syndrome (leukemic stage of CTCL) undergoing an approved FDA therapy, extracorporeal photopheresis (ECP). * Objective II: Evaluate antigen loading of the DCs. * Objective III: Test the functional capacities of the DCs derived from CTCL subjects to overcome immune tolerance to the tumor cells ex-vivo, by using modified Elispot assay in conjunction with Granzyme B Elispot assay as a measurement of cytotoxicity.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Name: Larisa J. Geskin, M.D.
Affiliation: University of Pittsburgh
Role: PRINCIPAL_INVESTIGATOR