Spots Global Cancer Trial Database for Thromboprophylaxis for Patients Undergoing Surgical Resection for Colon Cancer
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Trial Identification
Brief Title: Thromboprophylaxis for Patients Undergoing Surgical Resection for Colon Cancer
Official Title: The Use of Extended Perioperative Low Molecular Weight Heparin to Improve Cancer Specific Survival Following Surgical Resection of Colon Cancer: A Pilot Randomized Controlled Trial
Study ID: NCT00967148
Interventions
Study Description
Brief Summary: The blood thinner "tinzaparin" might increase survival in patients with colon cancer undergoing surgical resection. The investigators want to assess if a trial allocating patients to prolonged treatment with tinzaparin versus standard of care is feasible.
Detailed Description: Cancer patients are at high risk of postoperative thrombosis and this risk remains elevated beyond the period of hospitalization. Thromboprophylaxis effectively reduces the risk of post operative VTE in cancer patients. Extended thromboprophylaxis beyond hospitalization (up to 30 days) with LMWH has been shown to further reduce the risk of postoperative VTE. Concurrently, there is a growing body of evidence to suggest that LMWH may have anti-cancer effects due to anti-metastatic properties and may improve survival in cancer patients, even in the absence of a documented VTE. Retrospective studies have shown that perioperative thromboprophylaxis (i.e., starting thromboprophylaxis before the surgery) seems to increase survival in cancer patients undergoing abdominal or pelvic cancer surgery with curative intent. The investigators propose to perform an open-label RCT to determine if thromboprophylaxis using tinzaparin 4,500 IU daily, starting from the time of decision to operate through the peri-operative period and extending for 4 weeks postoperatively, is feasible.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ottawa Health Research Institute, Ottawa, Ontario, Canada
Contact Details
Name: Marc Carrier, MD MSc
Affiliation: Ottawa Hospital Research Institute
Role: PRINCIPAL_INVESTIGATOR
Name: Rebecca Auer, MD MSc
Affiliation: Ottawa Hospital Research Institute
Role: PRINCIPAL_INVESTIGATOR
Name: Tim Asmis, MD
Affiliation: Ottawa Hospital
Role: STUDY_CHAIR
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