Spots Global Cancer Trial Database for A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
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Trial Identification
Brief Title: A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Official Title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Study ID: NCT03690388
Conditions
Study Description
Brief Summary: The objective of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior vascular endothelial growth factor receptor (VEGFR)-Targeted therapy.
Detailed Description:
Eligibility
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Exelixis Clinical Site #2, Newport Beach, California, United States
Exelixis Clinical Site #98, Sacramento, California, United States
Exelixis Clinical Site #69, San Francisco, California, United States
Exelixis Clinical Site #10, Stanford, California, United States
Exelixis Clinical Site #3, Torrance, California, United States
Exelixis Clinical Site #9, Aurora, Colorado, United States
Exelixis Clinical Site #21, New Haven, Connecticut, United States
Exelixis Clinical Site #4, Washington, District of Columbia, United States
Exelixis Clinical Site #94, Miami, Florida, United States
Exelixis Clinical Site #93, Orlando, Florida, United States
Exelixis Clinical Site #6, Tampa, Florida, United States
Exelixis Clinical Site #164, Chicago, Illinois, United States
Exelixis Clinical Site #54, Lexington, Kentucky, United States
Exelixis Clinical Site #153, Boston, Massachusetts, United States
Exelixis Clinical Site #80, Ann Arbor, Michigan, United States
Exelixis Clinical Site #78, Detroit, Michigan, United States
Exelixis Clinical Site #22, Detroit, Michigan, United States
Exelixis Clinical Site #63, Columbia, Missouri, United States
Exelixis Clinical Site #42, Saint Louis, Missouri, United States
Exelixis Clinical Site #11, Omaha, Nebraska, United States
Exelixis Clinical Site #118, Morristown, New Jersey, United States
Exelixis Clinical Site #76, Charlotte, North Carolina, United States
Exelixis Clinical Site #19, Durham, North Carolina, United States
Exelixis Clinical Site #7, Cincinnati, Ohio, United States
Exelixis Clinical Site #5, Bethlehem, Pennsylvania, United States
Exelixis Clinical Site #1, Philadelphia, Pennsylvania, United States
Exelixis Clinical Site #75, Pittsburgh, Pennsylvania, United States
Exelixis Clinical Site #134, Charleston, South Carolina, United States
Exelixis Clinical Site #68, Nashville, Tennessee, United States
Exelixis Clinical Site #8, Houston, Texas, United States
Exelixis Clinical Site #113, Seattle, Washington, United States
Exelixis Clinical Site #96, Pergamino, Buenos Aires, Argentina
Exelixis Clinical Site #97, Caba, , Argentina
Exelixis Clinical Site #129, Córdoba, , Argentina
Exelixis Clinical Site #17, St. Leonards, New South Wales, Australia
Exelixis Clinical Site #25, Waratah, New South Wales, Australia
Exelixis Clinical Site #86, Bedford Park, South Australia, Australia
Exelixis Clinical Site #24, Melbourne, Victoria, Australia
Exelixis Clinical Site #12, Herston, , Australia
Exelixis Clinical Site #62, Salzburg, , Austria
Exelixis Clinical Site #119, Vienna, , Austria
Exelixis Clinical Site #90, Anderlecht, , Belgium
Exelixis Clinical Site #31, Brussels, , Belgium
Exelixis Clinical Site #26, Edegem, , Belgium
Exelixis Clinical Site #74, Edegem, , Belgium
Exelixis Clinical Site #100, Gent, , Belgium
Exelixis Clinical Site #27, Namur, , Belgium
Exelixis Clinical Site #35, Cascavel, Parana, Brazil
Exelixis Clinical Site #39, Porto Alegre, Rio Grande Do Sul, Brazil
Exelixis Clinical Site #140, Porto Alegre, Rio Grande Do Sul, Brazil
Exelixis Clinical Site #38, Porto Alegre, Rio Grande Do Sul, Brazil
Exelixis Clinical Site #40, Sao Jose do Rio Preto, Sao Paulo, Brazil
Exelixis Clinical Site #116, Ribeirão Preto, São Paulo, Brazil
Exelixis Clinical Site #92, Rio De Janeiro, , Brazil
Exelixis Clinical Site #47, Sao Paulo, , Brazil
Exelixis Clinical Site #20, Calgary, Alberta, Canada
Exelixis Clinical Site #18, Edmonton, Alberta, Canada
Exelixis Clinical Site #107, London, Ontario, Canada
Exelixis Clinical Site #83, Toronto, Ontario, Canada
Exelixis Clinical Site #145, Osijek, , Croatia
Exelixis Clinical Site #137, Zagreb, , Croatia
Exelixis Clinical Site #138, Zagreb, , Croatia
Exelixis Clinical Site #105, Brno, , Czechia
Exelixis Clinical Site #104, Olomouc, , Czechia
Exelixis Clinical Site #32, Dijon, Bourgogne-Franche-Comte, France
Exelixis Clinical Site #44, Villejuif, Ile De France, France
Exelixis Clinical Site #67, Bordeaux, Nouvelle - Aquitaine, France
Exelixis Clinical Site #45, Angers, Pays De La Loire, France
Exelixis Clinical Site #72, Marseille, Provence-Alpes-Cote d'Azur, France
Exelixis Clinical Site #102, Besançon, , France
Exelixis Clinical Site #91, Lyon Cedex 08, , France
Exelixis Clinical Site #82, Nice, , France
Exelixis Clinical Site #152, Paris, , France
Exelixis Clinical Site #95, Strasbourg Cedex, , France
Exelixis Clinical Site #121, Tübingen, Baden-Württemberg, Germany
Exelixis Clinical Site #156, Würzburg, Bayern, Germany
Exelixis Clinical Site #125, Marburg, Hesse, Germany
Exelixis Clinical Site #163, Hannover, Lower Saxony, Germany
Exelixis Clinical Site #124, Magdeburg, Sachsen-Anhalt, Germany
Exelixis Clinical Site #151, Dresden, Saxony, Germany
Exelixis Clinical Site #155, Aachen, , Germany
Exelixis Clinical Site #131, Bonn, , Germany
Exelixis Clinical Site #154, Essen, , Germany
Exelixis Clinical Site #160, Freiburg, , Germany
Exelixis Clinical Site #159, Hamburg, , Germany
Exelixis Clinical Site #139, München, , Germany
Exelixis Clinical Site #28, Hong Kong, , Hong Kong
Exelixis Clinical Site #46, Budapest, , Hungary
Exelixis Clinical Site #37, Pecs, , Hungary
Exelixis Clinical Site #43, Haifa, , Israel
Exelixis Clinical Site #41, Jerusalem, , Israel
Exelixis Clinical Site #58, Petah tikva, , Israel
Exelixis Clinical Site #109, Viagrande, Catania, Italy
Exelixis Clinical Site #135, Catania, CT, Italy
Exelixis Clinical Site #132, Meldola, Forlì - Cesena, Italy
Exelixis Clinical Site #144, Genova, GE, Italy
Exelixis Clinical Site #143, Rozzano, Milano, Italy
Exelixis Clinical Site #29, Pisa, PI, Italy
Exelixis Clinical Site #120, Torino, TO, Italy
Exelixis Clinical Site #103, Milano, , Italy
Exelixis Clinical Site #110, Milano, , Italy
Exelixis Clinical Site #115, Milano, , Italy
Exelixis Clinical Site #108, Napoli, , Italy
Exelixis Clinical Site #56, Napoli, , Italy
Exelixis Clinical Site #123, Padova, , Italy
Exelixis Clinical Site #87, Roma, , Italy
Exelixis Clinical Site #127, Roma, , Italy
Exelixis Clinical Site #111, Siena, , Italy
Exelixis Clinical Site #70, Busan, , Korea, Republic of
Exelixis Clinical Site #79, Gyeonggi-do, , Korea, Republic of
Exelixis Clinical Site #36, Seoul, , Korea, Republic of
Exelixis Clinical Site #34, Seoul, , Korea, Republic of
Exelixis Clinical Site #158, Tuxtla Gutiérrez, Chiapas, Mexico
Exelixis Clinical Site #133, Ciudad de Mèxico, , Mexico
Exelixis Clinical Site #147, Ciudad de México, , Mexico
Exelixis Clinical Site #148, Ciudad de México, , Mexico
Exelixis Clinical Site #161, San Luis Potosí, , Mexico
Exelixis Clinical Site #128, Amsterdam, Noord-Holland, Netherlands
Exelixis Clinical Site #117, Leiden, Zuid-Holland, Netherlands
Exelixis Clinical Site #15, Warszawa, Mazowieckie, Poland
Exelixis Clinical Site #61, Gliwice, Slaskie, Poland
Exelixis Clinical Site #59, Poznan, Wielkopolskie, Poland
Exelixis Clinical Site #149, Cluj-Napoca, Cluj, Romania
Exelixis Clinical Site #150, Craiova, Dolj, Romania
Exelixis Clinical Site #142, Timişoara, Timis, Romania
Exelixis Clinical Site #146, Bucuresti, , Romania
Exelixis Clinical Site #48, Obninsk, Kaluzhiskiy Region, Russian Federation
Exelixis Clinical Site #55, Kislino, Kursk Region, Russian Federation
Exelixis Clinical Site #157, Tyumen, Tyumen Region, Russian Federation
Exelixis Clinical Site #49, Moscow, , Russian Federation
Exelixis Clinical Site #53, Moscow, , Russian Federation
Exelixis Clinical Site #84, Moscow, , Russian Federation
Exelixis Clinical Site #85, Moscow, , Russian Federation
Exelixis Clinical Site #106, Omsk, , Russian Federation
Exelixis Clinical Site #89, Saint Petersburg, , Russian Federation
Exelixis Clinical Site #52, Samara, , Russian Federation
Exelixis Clinical Site #66, Yaroslavl, , Russian Federation
Exelixis Clinical Site #14, Barcelona, , Spain
Exelixis Clinical Site #99, Barcelona, , Spain
Exelixis Clinical Site #114, Madrid, , Spain
Exelixis Clinical Site #30, Madrid, , Spain
Exelixis Clinical Site #13, Madrid, , Spain
Exelixis Clinical Site #16, Madrid, , Spain
Exelixis Clinical Site #33, Madrid, , Spain
Exelixis Clinical Site #73, Madrid, , Spain
Exelixis Clinical Site #23, Madrid, , Spain
Exelixis Clinical Site #81, Málaga, , Spain
Exelixis Clinical Site #136, Tainan, , Taiwan
Exelixis Clinical Site #112, Tainan, , Taiwan
Exelixis Clinical Site #77, Taipei, , Taiwan
Exelixis Clinical Site #101, Taipei, , Taiwan
Exelixis Clinical Site #126, Bangkok Noi, Bangkok, Thailand
Exelixis Clinical Site #122, Pathum Wan, Bangkok, Thailand
Exelixis Clinical Site #141, Ratchathewi, Bangkok, Thailand
Exelixis Clinical Site #130, Hat Yai, Songkla, Thailand
Exelixis Clinical Site #88, Birmingham, England, United Kingdom
Exelixis Clinical Site #71, Bristol, England, United Kingdom
Exelixis Clinical Site #162, London, England, United Kingdom
Exelixis Clinical Site #51, Oxford, England, United Kingdom
Exelixis Clinical Site #64, Aberdeen, Scotland, United Kingdom
Exelixis Clinical Site #50, Glasgow, Scotland, United Kingdom
Exelixis Clinical Site #60, Cardiff, Wales, United Kingdom
Exelixis Clinical Site #65, Manchester, , United Kingdom
Exelixis Clinical Site #57, Sheffield, , United Kingdom
Contact Details
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