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Brief Title: Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma
Official Title: Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma
Study ID: NCT03797170
Brief Summary: In Europe diffuse large B-cell lymphoma (DLBCL) is a rare disease whereas in Italy it is not. Approximately 40% of DLBCL patients has refractory disease or will relapse after initial response. In onco-hematology, a role for gut microbiota (GM) in mediating immune activation in response to chemotherapy, has been suggested. In this scenario, the Investigators hypothesized that GM could play an important role in DLBCL prognosis and response to treatment, establishing a connection between lifestyle and clinical response. The project is aimed to the study of the functional GM layout in association with specific patterns of treatment response in de novo DLBCL undergoing standard first line chemo-immunotherapy. Results may build the scientific basis to design new and personalized intervention strategies (both in treatment approach and in life-style recommendations), to enhance clinical response and reduction of disease refractoriness through modulation of the gut microbial ecosystem.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola, FC, Italy
Institute Of Hematology "Seràgnoli", Bologna, , Italy
Name: Pier Luigi L Zinzani, Professor
Affiliation: Institute of Hematology "L. e A. Seràgnoli", University of Bologna
Role: PRINCIPAL_INVESTIGATOR