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Spots Global Cancer Trial Database for Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma

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Trial Identification

Brief Title: Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma

Official Title: Design of New Personalized Therapeutic Approaches for Diffuse Large B-cell Lymphoma

Study ID: NCT03797170

Study Description

Brief Summary: In Europe diffuse large B-cell lymphoma (DLBCL) is a rare disease whereas in Italy it is not. Approximately 40% of DLBCL patients has refractory disease or will relapse after initial response. In onco-hematology, a role for gut microbiota (GM) in mediating immune activation in response to chemotherapy, has been suggested. In this scenario, the Investigators hypothesized that GM could play an important role in DLBCL prognosis and response to treatment, establishing a connection between lifestyle and clinical response. The project is aimed to the study of the functional GM layout in association with specific patterns of treatment response in de novo DLBCL undergoing standard first line chemo-immunotherapy. Results may build the scientific basis to design new and personalized intervention strategies (both in treatment approach and in life-style recommendations), to enhance clinical response and reduction of disease refractoriness through modulation of the gut microbial ecosystem.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola, FC, Italy

Institute Of Hematology "Seràgnoli", Bologna, , Italy

Contact Details

Name: Pier Luigi L Zinzani, Professor

Affiliation: Institute of Hematology "L. e A. Seràgnoli", University of Bologna

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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