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Spots Global Cancer Trial Database for Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Official Title: A Randomized, Double-blind, Placebo-Controlled, Active-Comparator, Multicenter, Phase 3 Study of Brentuximab Vedotin or Placebo in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Study ID: NCT04404283

Study Description

Brief Summary: Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Participants will be randomly assigned to get either brentuximab vedotin or placebo. The placebo will look like brentuximab vedotin, but has no medicine in it. Since the study is "blinded," participants and their doctors will not know whether a participant gets brentuximab vedotin or placebo. All participants in the study will get rituximab and lenalidomide. These are drugs that can be used to treat DLBCL.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Central Alabama Research, Birmingham, Alabama, United States

Alabama Oncology, Birmingham, Alabama, United States

Arizona Oncology Associates, PC - NAHOA, Goodyear, Arizona, United States

The Oncology Institute of Hope & Innovation - California, Riverside, California, United States

University of California Davis, Sacramento, California, United States

Lundquist Institute/Harbor-UCLA, Torrance, California, United States

Florida Cancer Specialists - South Region, Fort Myers, Florida, United States

Florida Cancer Specialists - North Region, Saint Petersburg, Florida, United States

Florida Cancer Specialists - East West Palm Beach, FL (SCRI), West Palm Beach, Florida, United States

Rush University Medical Center, Chicago, Illinois, United States

Illinois Cancer Specialists, Niles, Illinois, United States

University of Maryland, Baltimore, Maryland, United States

Karmanos Cancer Institute / Wayne State University, Detroit, Michigan, United States

Henry Ford Health System, Detroit, Michigan, United States

Cancer and Hematology Centers of Western Michigan / Lemmen-Holton Cancer Pavilion, Grand Rapids, Michigan, United States

Ascension St John Hospital, Grosse Pointe Woods, Michigan, United States

Mayo Clinic Rochester, Rochester, Minnesota, United States

HCA Midwest Health Kansas City, Kansas City, Missouri, United States

Saint Louis University, Saint Louis, Missouri, United States

Washington University in St Louis, Saint Louis, Missouri, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

MD Anderson Cancer Center at Cooper Health, Camden, New Jersey, United States

Summit Medical Group, Florham Park, New Jersey, United States

New York Cancer and Blood Specialists, Port Jefferson Station, New York, United States

Oncology Hematology Care, Cincinnati, Ohio, United States

University of Cincinnati Cancer Institute, Cincinnati, Ohio, United States

Willamette Valley Cancer Institute and Research Center, Eugene, Oregon, United States

Roper St. Francis Healthcare, Charleston, South Carolina, United States

Medical University of South Carolina/Hollings Cancer Center, Charleston, South Carolina, United States

Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina, United States

Prisma Health, Greenville, South Carolina, United States

University of Tennessee, Knoxville, Tennessee, United States

Texas Oncology - Austin Midtown, Austin, Texas, United States

Texas Oncology - San Antonio Medical Center, San Antonio, Texas, United States

University of Virginia, Charlottesville, Virginia, United States

Northwest Cancer Specialists, P.C., Vancouver, Washington, United States

Carbone Cancer Center / University of Wisconsin, Madison, Wisconsin, United States

Aurora Health Care, Inc, Wauwatosa, Wisconsin, United States

Royal Adelaide Hospital, Adelaide, Other, Australia

Central Coast Local Health District (Gosford and Wyong Hospitals), Gosford, Other, Australia

Royal Hobart Hospital, Hobart, Other, Australia

Hollywood Haematology, Nedlands, Other, Australia

Royal North Shore Hospital, Saint Leonards, Other, Australia

Ziekenhuis Netwerk Antwerpen Campus Stuivenberg, Antwerpen, Other, Belgium

Universitair Ziekenhuis Antwerpen, Edegem, Other, Belgium

Universitair Ziekenhuis Gent, Gent, Other, Belgium

Hopital de Jolimont, Haine-Saint-Paul, Other, Belgium

Clinique Saint Pierre, Ottignies, Other, Belgium

AZ Delta - Campus Wilgenstraat, Roeselare, Other, Belgium

CHU UCL Namur, Yvoir, Other, Belgium

H. Bliss Murphy Cancer Centre / Eastern Regional Health Authority, St John's, Newfoundland and Labrador, Canada

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

William Osler Health Sciences, East Brampton, Ontario, Canada

London Health Sciences Centre - Victoria Hospital, London, Ontario, Canada

Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC), Oshawa, Ontario, Canada

University of Ottawa / Ottawa General Hospital, Ottawa, Ontario, Canada

CISSS de la Monteregie-Centre, Greenfield Park, Quebec, Canada

CIUSSS de L'Est de l'lle de Montreal / installation Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

CIUSS NIM/Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada

Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie, Hradec Kralove, Other, Czechia

Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Other, Czechia

Vseobecna fakultni nemocnice v Praze, Praha 2, Other, Czechia

Aalborg Universitetshospital, Aalborg, Other, Denmark

Aarhus University Hospital, Aarhus N, Other, Denmark

Rigshospitalet, Copenhagen, Other, Denmark

Zealand University Hospital (Roskilde Sygehus), Roskilde, Other, Denmark

Center Hospitalier Universitaire d' Angers, Angers Cedex 9, Other, France

Centre de Lutte Contre le Cancer (CLCC) - Institut Bergonie, Bordeaux, Other, France

Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital Morvan, Brest Cedex, Other, France

CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies, Cedex 9, Other, France

Centre Hospitalier Metropole Savoie - Chambery, Chambery, Other, France

Centre Hospitalier Sud Francilien, Corbeil-Essonnes, Other, France

Centre Hospitalier Universitaire (CHU) Dijon Bourgogne, Dijon, Other, France

Centre Hospitalier Universitaire de Grenoble, Grenoble, Other, France

Centre Hospitalier Le Mans, Le Mans, Other, France

Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren, Limoges Cedex, Other, France

Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes, Lyon, Other, France

Centre Hospitalier Regional Metz-Thionville, Hopital Mercy, Metz, Other, France

Hopital Emile Muller, Mulhouse, Other, France

Centre Hospitalier Universitaire Nantes-Hotel Dieu, Nantes cedex 1, Other, France

Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice Cedex 2, Other, France

Centre Hospitalier de Perpignan, Perpignan CEDEX, Other, France

CHU Bordeaux Hopital Haut-Leveque, Pessac Cedex, Other, France

Centre Hospitalier Lyon Sud, Pierre-Benite Cedex, Other, France

Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer, Rouen, Other, France

Institut de Cancerologie Hematologie Universitaire de Saint Etienne (I.CHU.SE), Saint Etienne Cedex 2, Other, France

Centre Hospitalier Universitaire de Nancy - Hopital de Brabois, Vandoeuvre-Les-Nancy Cedex 9, Other, France

Institut Gustave Roussy, Villejuif Cedex, Other, France

CHU Tours - Hopital Bretonneau, Paris, , France

Hopital Saint-Antoine, Paris, , France

Medizinische Klinik & Poliklinik III (Bonn)nUniversitätsklinikum Bonn, Bonn, Other, Germany

Stadtisches Klinikum Brandenburg GmbH, Brandenburg, Other, Germany

Universitaetsklinikum Dusseldorf, Duesseldorf, Other, Germany

Universitaetsklinikum Halle (Saale), Halle (S.), Other, Germany

Centro di Riferimento Oncologico di Aviano, Aviano (Pordenone), Other, Italy

IRCCS Istituto Tumori Giovanni Paolo II, Bari, Other, Italy

Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna, Other, Italy

Azienda Ospedaliero Universitaria Careggi, Firenze, Other, Italy

Azienda Ospedaliera Universitaria San Martino, Genova, Other, Italy

Azienda Ospedaliera Cardinale Giovanni Panico, Lecce, Other, Italy

IRCCS Ospedale San Raffaele, Milano, Other, Italy

Istituto Europeo di Oncologia, Milano, Other, Italy

Azienda Ospedaliera Universitaria (AOU) Federico II, Napoli, Other, Italy

AOOR Villa Sofia Cervello - Presidio V. Cervello, Palermo, Other, Italy

Azienda Ospedaliero Universitaria di Parma, Parma, Other, Italy

IRCSS Policlinico San Matteo, Pavia, Other, Italy

Universita degli Studi di Perugia Azienda Ospedaliera di Perugia (Ospedale Santa Maria della Misericordia), Perugia, Other, Italy

UO Ematologia Ravenna, Ravenna, Other, Italy

AUSL della Romagna Ospedale Infermi, Rimini, Other, Italy

Policlinico Universitario Agostino Gemelli, Roma, Other, Italy

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo (Foggia), Other, Italy

Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Other, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, , Italy

Dong-A University Hospital, Busan, Other, Korea, Republic of

Pusan National University Hospital, Busan, Other, Korea, Republic of

Kosin University Gospel Hospital, Busan, Other, Korea, Republic of

Inje University Busan-Paik Hospital, Busan, Other, Korea, Republic of

Keimyung University Dongsan Medical Center, Daegu, Other, Korea, Republic of

National Cancer Center, Goyang-si, Other, Korea, Republic of

Gachon University Gil Medical Center, Incheon, Other, Korea, Republic of

Jeonbuk National University Hospital, Jeonju-Si, Other, Korea, Republic of

Severance Hospital, Yonsei University Health System, Seoul, Other, Korea, Republic of

Soon Chun Hyang University Hospital Seoul, Seoul, Other, Korea, Republic of

Asan Medical Center - Oncology, Seoul, Other, Korea, Republic of

Samsung Medical Center, Seoul, Other, Korea, Republic of

Ewha Womans University Mokdong Hospital, Seoul, Other, Korea, Republic of

Seoul Saint Mary's Hospital, Seoul, Other, Korea, Republic of

St. Vincent's Hospital, The Catholic University of Korea, Suwon-si, Other, Korea, Republic of

Slingeland ziekenhuis, Doetinchem, Other, Netherlands

Pratia Onkologia Katowice, Katowice, Other, Poland

Pratia MCM Krakow, Krakow, Other, Poland

Warmian-Masurian Cancer Center of The Ministry of The Interior and Administraton's Hospital, Olsztyn, Other, Poland

Pratia Poznan, Skorzewo, Other, Poland

Nasz Lekarz Osrodek Badan Klinicznych, Torun, Other, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Warsaw, Other, Poland

Hospital Universitari Germans Trias i Pujol, Badalona, Other, Spain

Hospital del Mar, Barcelona, Other, Spain

Hospital Universitari Vall d'Hebron, Barcelona, Other, Spain

Hospital de la Santa Creu i Sant Pau, Barcelona, Other, Spain

Hospital San Pedro de Alcantara, Caceres, Other, Spain

Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), L'Hospitalet de Llobregat, Other, Spain

Clinica Universidad de Navarra, Madrid, Other, Spain

Hospital Universitario Infanta Leonor, Madrid, Other, Spain

Hospital Puerta de Hierro Majadahonda, Madrid, Other, Spain

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Other, Spain

Hospital Universitario 12 de Octubre, Madrid, Other, Spain

Hospital Universitario La Paz, Madrid, Other, Spain

Hospital Regional Universitario de Malaga - Hospital General, Malaga, Other, Spain

Hospital Costa del Sol, Marbella, Other, Spain

Hospital Universitario Central de Asturias, Oviedo, Other, Spain

Clinica Universidad de Navarra, Pamplona, Other, Spain

Complejo Hospitalario de Navarra, Pamplona, Other, Spain

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Other, Spain

Hospital Clínico Universitario de Salamanca, Salamanca, Other, Spain

Universitatsspital Basel, Basel, Other, Switzerland

Kantonsspital Winterthur (KSW), Winterthur, Other, Switzerland

Universitatsspital Zurich, Zurich, Other, Switzerland

Chang Gung Memorial Hospital - Kaohsiung, Kaohsiung, Other, Taiwan

China Medical University Hospital, Taichung, Other, Taiwan

Chang Gung Memorial Hospital - Taoyuan, Tainan, Other, Taiwan

National Cheng-Kung University Hospital, Tainan, Other, Taiwan

Chi Mei Hospital Liouying, Tainan, Other, Taiwan

National Taiwan University Hospital, Taipei, Other, Taiwan

Taipei Veterans General Hospital, Taipei, Other, Taiwan

East Sussex Healthcare NHS Trust, Eastbourne, Other, United Kingdom

University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, Other, United Kingdom

St Bartholomew's Hospital, London, Other, United Kingdom

Guy's and St Thomas' NHS Foundation, London, Other, United Kingdom

The Royal Marsden Hospital, London, Other, United Kingdom

Maidstone and Tunbridge Wells NHS Trust, Maidstone, Other, United Kingdom

The Royal Marsden Hospital (Surrey), Sutton, Other, United Kingdom

Singleton Hospital, Swansea, Other, United Kingdom

Contact Details

Name: Medical Monitor

Affiliation: Seagen Inc.

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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