Spots Global Cancer Trial Database for Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma
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Trial Identification
Brief Title: Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma
Official Title: Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile
Study ID: NCT01606605
Conditions
Interventions
Study Description
Brief Summary: The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
Detailed Description: 1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay * Diffuse large B-cell lymphoma patients * Paraffin-embedded tissue * End points: Progression-free survival, overall survival * Statistics: Leave one-out method 2. Nano string assay for microRNA * Diffuse large B-cell lymphoma patients * Paraffin-embedded tissue * End points: Progression-free survival, overall survival * Statistics: Leave one-out method
Eligibility
Minimum Age: 15 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Samsung Cancer Research Institute, Seoul, , Korea, Republic of
Contact Details
Name: Won Seog Kim, MD, PhD
Affiliation: Samsung Medical Center Cancer Research Institute
Role: PRINCIPAL_INVESTIGATOR
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