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Brief Title: A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
Official Title: A Phase 3, Randomized, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination With R-CHOP Compared to R-CHOP in Subjects With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
Study ID: NCT05578976
Brief Summary: B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed. Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study doctors put the participants in groups called treatment arms. Participants will receive epcoritamab combined with R-CHOP, followed by epcoritamab or R-CHOP followed by rituximab will be explored. Approximately 900 adult participants with with newly diagnosed DLBCL will be enrolled in the study in approximately 315 sites in globally. In the Arm 1, participants will receive subcutaneous epcoritamab combined with intravenous and oral R-CHOP followed by subcutaneous epcoritamab in 21-day cycles. In the Arm 2, participants will receive intravenous and oral R-CHOP followed by intravenous rituximab in 21-day cycles. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Arizona Cancer Center - North Campus /ID# 227463, Tucson, Arizona, United States
University of Arkansas for Medical Sciences /ID# 225703, Little Rock, Arkansas, United States
Orange Coast Memorial Medical Center /ID# 229632, Fountain Valley, California, United States
Saddleback Memorial Medical Center /ID# 229631, Laguna Hills, California, United States
Long Beach Memorial Medical Ct /ID# 228996, Long Beach, California, United States
University of Southern California /ID# 225443, Los Angeles, California, United States
University of California, Los Angeles /ID# 226887, Los Angeles, California, United States
Cancer Specialists of North Florida /ID# 226826, Jacksonville, Florida, United States
UF Health Cancer Center at Orlando Health /ID# 232626, Orlando, Florida, United States
Southern IL Univ School of Med /ID# 228999, Springfield, Illinois, United States
Parkview Cancer Institute /ID# 227026, Fort Wayne, Indiana, United States
Goshen Center for Cancer Care /ID# 225534, Goshen, Indiana, United States
Mission Cancer and Blood /ID# 261945, Des Moines, Iowa, United States
Norton Cancer Institute - St Matthews /ID# 225420, Louisville, Kentucky, United States
American Oncology Partners of Maryland, PA /ID# 226859, Bethesda, Maryland, United States
Trinity Health St. Joseph Mercy Ann Arbor /ID# 228206, Ypsilanti, Michigan, United States
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 226680, Saint Louis Park, Minnesota, United States
Intermountain Health - St Vincent Regional Hospital - Cancer Centers of Montana /ID# 259014, Billings, Montana, United States
NHO Revive Research Institute, LLC /ID# 261113, Lincoln, Nebraska, United States
Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654, East Brunswick, New Jersey, United States
University of New Mexico /ID# 227332, Albuquerque, New Mexico, United States
Presbyterian Kaseman Hospital /ID# 262084, Albuquerque, New Mexico, United States
Presbyterian Rust Medical Center /ID# 262068, Rio Rancho, New Mexico, United States
NYU Langone Hospital - Long Island /ID# 262412, Mineola, New York, United States
NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141, New York, New York, United States
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379, New York, New York, United States
Novant Health Presbyterian Medical Center /ID# 227753, Charlotte, North Carolina, United States
Novant Health Forsyth Medical Center /ID# 228339, Winston-Salem, North Carolina, United States
University of Cincinnati /ID# 225374, Cincinnati, Ohio, United States
Kaiser Permanente - Northwest /ID# 225488, Portland, Oregon, United States
Millennium Research & Clinical Development /ID# 228284, Kingwood, Texas, United States
Intermountain Medical Center /ID# 231184, Murray, Utah, United States
University of Virginia Cancer Center - West Complex /ID# 225433, Charlottesville, Virginia, United States
Vista Oncology - East Olympia /ID# 229375, Olympia, Washington, United States
Multicare Institute for Research and Innovation /ID# 225432, Tacoma, Washington, United States
Liverpool Hospital /ID# 230072, Liverpool, New South Wales, Australia
Royal Adelaide Hospital /ID# 225683, Adelaide, South Australia, Australia
Monash Medical Centre /ID# 225680, Clayton, Victoria, Australia
Austin Health /ID# 225716, Heidelberg, Victoria, Australia
Alfred Health /ID# 225999, Melbourne, Victoria, Australia
Hollywood Private Hospital /ID# 251837, Nedlands, Western Australia, Australia
Perth Blood Institute Ltd /ID# 225679, Nedlands, Western Australia, Australia
Royal Perth Hospital /ID# 226583, Perth, Western Australia, Australia
Universitaetsklinikum St. Poelten /ID# 234016, Sankt Poelten, Niederoesterreich, Austria
Medizinische Universitaet Wien /ID# 252095, Vienna, Wien, Austria
Klinik Ottakring /ID# 243941, Vienna, Wien, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228360, Salzburg, , Austria
Cliniques Universitaires UCL Saint-Luc /ID# 225737, Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Hospital La Louviere Site Jolimont - Helora /ID# 225738, La Louvière, Hainaut, Belgium
CHU de Liège /ID# 225952, Liège, Liege, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 225742, Yvoir, Namur, Belgium
UZ Gent /ID# 250031, Gent, Oost-Vlaanderen, Belgium
Vitaz /Id# 226153, Sint-Niklaas, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 225951, Leuven, Vlaams-Brabant, Belgium
AZ-Delta /ID# 225736, Roeselare, West-Vlaanderen, Belgium
Institut Jules Bordet /ID# 225954, Anderlecht, , Belgium
ZNA Middelheim /ID# 225741, Antwerp, , Belgium
ZNA Cadix /ID# 264327, Antwerp, , Belgium
AZ Sint-Jan Brugge /ID# 225735, Brugge, , Belgium
Hospital de Clinicas da Universidade Federal do Parana /ID# 226027, Curitiba, Parana, Brazil
Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065, Jaú, Sao Paulo, Brazil
Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809, São Paulo, Sao Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 252832, São Paulo, Sao Paulo, Brazil
Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023, Sao Paulo, , Brazil
Hospital Alemao Oswaldo Cruz /ID# 252833, Sao Paulo, , Brazil
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 226048, Sao Paulo, , Brazil
UMHAT Sveti Georgi /ID# 245780, Plovdiv, , Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616, Sofia, , Bulgaria
UMHAT Sveti Ivan Rilski /ID# 244615, Sofia, , Bulgaria
SHAT Hematologic Diseases /ID# 250102, Sofia, , Bulgaria
Tom Baker Cancer Centre /ID# 226077, Calgary, Alberta, Canada
BC Cancer - Vancouver /ID# 230573, Vancouver, British Columbia, Canada
William Osler Health System /ID# 250973, Brampton, Ontario, Canada
Juravinski Cancer Centre /ID# 226084, Hamilton, Ontario, Canada
Saskatoon Cancer Centre /ID# 226082, Saskatoon, Saskatchewan, Canada
The Fifth Medical Center of PLA General Hospital /ID# 230941, Beijing, Beijing, China
Beijing Cancer Hospital /ID# 229819, Beijing, Beijing, China
Peking University Third Hospital /ID# 230975, Beijing, Beijing, China
Fujian Provincial Cancer Hospital /ID# 238430, Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University /ID# 238426, Xiamen, Fujian, China
Sun Yat-Sen University Cancer Center /ID# 238371, Guangzhou, Guangdong, China
Guangdong Provincial People's Hospital /ID# 230945, Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University /ID# 238436, Guangzhou, Guangdong, China
Harbin Medical University Cancer Hospital /Id# 241755, Harbin, Heilongjiang, China
Henan Cancer Hospital /ID# 230398, Zhengzhou, Henan, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152, Wuhan, Hubei, China
Hubei Cancer Hospital /ID# 232256, Wuhan, Hubei, China
The First Affiliated Hospital of Soochow University /ID# 232569, Suzhou, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical College /ID# 233174, Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 230399, Nanchang, Jiangxi, China
Jiangxi Provincial Cancer Hospital /ID# 233379, Nanchang, Jiangxi, China
The First Hospital of Jilin University /ID# 239618, Changchun, Jilin, China
The First Hospital of China Medical University /ID# 233201, Shenyang, Liaoning, China
Shandong Cancer Hospital /ID# 233200, Jinan, Shandong, China
Fudan University Cancer Hospital /ID# 251516, Shanghai, Shanghai, China
Tianjin Cancer Hospital /ID# 230974, Tianjin, Tianjin, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 259904, Tianjin, Tianjin, China
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387, Hangzhou, Zhejiang, China
The second affiliated hospital of Zhejiang University school of medicine /ID# 231249, Hangzhou, Zhejiang, China
Zhejiang Cancer hospital /ID# 231388, Hangzhou, Zhejiang, China
Clinical Hospital Dubrava /ID# 251809, Zagreb, Grad Zagreb, Croatia
Klinicka bolnica Merkur /ID# 252481, Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 250709, Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Rijeka /ID# 251811, Rijeka, Primorsko-goranska Zupanija, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 250729, Split, Splitsko-dalmatinska Zupanija, Croatia
Opca bolnica Dr. Josip Bencevic /ID# 251812, Slavonski Brod, , Croatia
Fakultni nemocnice Brno /ID# 225953, Brno, , Czechia
Fakultni nemocnice Hradec Kralove /ID# 225955, Hradec Kralove, , Czechia
Fakultni Nemocnice Ostrava /ID# 225957, Ostrava, , Czechia
Duplicate_Fakultni Nemocnice v Motole /ID# 225958, Prague, , Czechia
Fakultni nemocnice Kralovske Vinohrady /ID# 225956, Praha, , Czechia
Vseobecna fakultni nemocnice v Praze /ID# 225396, Praha, , Czechia
Rigshospitalet /ID# 226576, Copenhagen Ø, Hovedstaden, Denmark
Aarhus Universitetshospital - Skejby /ID# 226594, Aarhus, Midtjylland, Denmark
Roskilde Sygehus /ID# 226597, Roskilde, Sjælland, Denmark
Odense University Hospital /ID# 226593, Odense C, Syddanmark, Denmark
Sygehus Lillebalt, Vejle /ID# 226592, Vejle, Syddanmark, Denmark
CHU de Nice - Hôpital Archet 1 /ID# 226127, Nice, Alpes-Maritimes, France
Institut Paoli-Calmettes /ID# 226557, Marseille, Bouches-du-Rhone, France
CHU de Rennes - PONTCHAILLOU /ID# 228207, Rennes, Bretagne, France
CHU Dijon /ID# 238345, Dijon, Cote-d Or, France
CHU Limoges - Dupuytren 1 /ID# 234235, Limoges CEDEX 1, Franche-Comte, France
CHU Montpellier - Hôpital Saint Eloi /ID# 228191, Montpellier Cedex 5, Herault, France
CHRU Nancy - Hopitaux de Brabois /ID# 226102, Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
CHRU Lille - Hopital Claude Huriez /ID# 226101, Lille, Nord, France
CHU de Nantes, Hotel Dieu -HME /ID# 226125, Nantes, Pays-de-la-Loire, France
Centre Hospitalier de la Cote Basque /ID# 249143, Bayonne, Pyrenees-Atlantiques, France
HCL - Hopital Lyon Sud /ID# 227086, Pierre Benite CEDEX, Rhone, France
CHU Amiens-Picardie Site Sud /ID# 238347, Amiens CEDEX 1, Somme, France
CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899, La Roche Sur Yon, Vendee, France
CHU Poitiers - La miletrie /ID# 226578, Poitiers, Vienne, France
Chu Angers /Id# 245931, Angers, , France
CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582, Caen, , France
Hôpitaux Universitaires Henri Mondor - Hôpital Henri Mondor /ID# 226560, Créteil, , France
CHU Grenoble - Hopital Michallon /ID# 226128, La Tronche, , France
AP-HP - Hopital Saint-Louis /ID# 226126, Paris, , France
Centre Henri Becquerel /ID# 226103, Rouen, , France
Institut Curie - site CLCC René Huguenin /ID# 253519, Saint-cloud, , France
General Hospital of Athens Laiko /ID# 225399, Athens, Attiki, Greece
Alexandra General Hospital /ID# 225402, Athens, Attiki, Greece
University General Hospital Attikon /ID# 225401, Athens, Attiki, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416, Athens, , Greece
University General Hospital of Ioannina /ID# 225400, Ioannina, , Greece
General University Hospital of Thessaloniki AXEPA /ID# 225398, Thessaloniki, , Greece
Theageneio Anticancer Hospital /ID# 225516, Thessaloniki, , Greece
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 257189, Gyor, Gyor-Moson-Sopron, Hungary
Debreceni Egyetem-Klinikai Kozpont /ID# 226821, Debrecen, Hajdu-Bihar, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245938, Kaposvár, Somogy, Hungary
Tolna Varmegyei Balassa Janos Korhaz /ID# 250063, Szekszard, Tolna, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 226846, Szombathely, Vas, Hungary
Semmelweis Egyetem /ID# 227239, Budapest, , Hungary
Orszagos Onkologiai Intezet /ID# 227294, Budapest, , Hungary
Szegedi Tudományegyetem /ID# 226838, Szeged, , Hungary
Rambam Health Care Campus /ID# 225981, Haifa, H_efa, Israel
Meir Medical Center /ID# 225612, Kfar Saba, HaMerkaz, Israel
Assuta Tel Aviv Medical Center /ID# 226066, Tel Aviv, HaMerkaz, Israel
The Chaim Sheba Medical Center /ID# 225600, Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 225891, Tel Aviv, Tel-Aviv, Israel
Shaare Zedek Medical Center /ID# 259796, Jerusalem, Yerushalayim, Israel
Hadassah /ID# 225614, Jerusalem, Yerushalayim, Israel
Rabin Medical Center /ID# 225862, Haifa, , Israel
Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 225554, San Giovanni Rotondo, Foggia, Italy
Ospedale San Raffaele IRCCS /ID# 225555, Milan, Milano, Italy
IEO -Istituto Europeo di Oncologia /ID# 225545, Milan, Milano, Italy
Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 225751, Candiolo, Torino, Italy
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 225542, Alessandria, , Italy
Centro di Riferimento Oncologico /ID# 225553, Aviano, , Italy
ASST Spedali civili di Brescia /ID# 225549, Brescia, , Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS /ID# 252192, Meldola, , Italy
Azienda Ospedaliera Universitaria Federico II /ID# 225543, Napoli, , Italy
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773, Novara, , Italy
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 225541, Palermo, , Italy
Azienda Ospedaliero Universitaria Pisana /ID# 225575, Pisa, , Italy
Ospedale Santa Maria delle Croci /ID# 225571, Ravenna, , Italy
NHO Nagoya Medical Center /ID# 230677, Nagoya-shi, Aichi, Japan
Aichi Cancer Center Hospital /ID# 226090, Nagoya-shi, Aichi, Japan
National Cancer Center Hospital East /ID# 250151, Kashiwa-shi, Chiba, Japan
Matsuyama Red Cross Hospital /ID# 251068, Matsuyama-shi, Ehime, Japan
National Hospital Organization Kyushu Cancer Center /ID# 251622, Fukuoka-shi, Fukuoka, Japan
Kyushu University Hospital /ID# 226091, Fukuoka-shi, Fukuoka, Japan
Fukushima Medical University Hospital /ID# 250869, Fukushima-shi, Fukushima, Japan
Hokkaido University Hospital /ID# 250149, Sapporo-shi, Hokkaido, Japan
Kobe City Medical Center General Hospital /ID# 250597, Kobe-shi, Hyogo, Japan
University of Tsukuba Hospital /ID# 251282, Tsukuba-shi, Ibaraki, Japan
Kanazawa University Hospital /ID# 251770, Kanazawa-shi, Ishikawa, Japan
Kagoshima University Hospital /ID# 250163, Kagoshima-shi, Kagoshima, Japan
Tokai University Hospital- Isehara Campus /ID# 251281, Isehara, Kanagawa, Japan
Tohoku University Hospital /ID# 250150, Sendai-shi, Miyagi, Japan
Kindai University Hospital /ID# 250160, Osakasayama-shi, Osaka, Japan
Osaka University Hospital /ID# 251283, Suita-shi, Osaka, Japan
National Cancer Center Hospital /ID# 226089, Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital Of JFCR /ID# 230269, Koto, Tokyo, Japan
Yamagata University Hospital /ID# 230003, Yamagata-shi, Yamagata, Japan
Okayama University Hospital /ID# 250161, Okayama, , Japan
Inje University - Busan Paik Hospital /ID# 232262, Busan, Busan Gwang Yeogsi, Korea, Republic of
Seoul National University Bundang Hospital /ID# 225763, Seongnam-si, Gyeonggido, Korea, Republic of
Keimyung University Dongsan Hospital /ID# 232264, Daegu, Gyeongsangbugdo, Korea, Republic of
Dong-A University Medical Center /ID# 228451, Busan, Gyeongsangnamdo, Korea, Republic of
Jeonbuk National University Hospital /ID# 232263, Jeonju, Jeonrabugdo, Korea, Republic of
Asan Medical Center /ID# 225758, Seoul, Seoul Teugbyeolsi, Korea, Republic of
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 225761, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Ulsan University Hospital /ID# 226971, Ulsan, Ulsan Gwang Yeogsi, Korea, Republic of
Seoul National University Hospital /ID# 225760, Seoul, , Korea, Republic of
Samsung Medical Center /ID# 225759, Seoul, , Korea, Republic of
Flevo Ziekenhuis /ID# 229606, Almere, Flevoland, Netherlands
Gelre Ziekenhuizen /ID# 229762, Apeldoorn, Gelderland, Netherlands
Amphia Ziekenhuis /ID# 229550, Breda, Noord-Brabant, Netherlands
Spaarne Gasthuis, Haarlem Zuid /ID# 229621, Haarlem, Noord-Holland, Netherlands
Tergooi /ID# 229772, Hilversum, Noord-Holland, Netherlands
Dijklander Ziekenhuis /ID# 229900, Hoorn Nh, Noord-Holland, Netherlands
Zaans Medisch Centrum /ID# 230614, Zaandam, Noord-Holland, Netherlands
Albert Schweitzer Ziekenhuis /ID# 229560, Dordrecht, Zuid-Holland, Netherlands
Noordwest Ziekenhuisgroep /ID# 230613, Alkmaar, , Netherlands
Meander Medisch Centrum /ID# 229608, Amersfoort, , Netherlands
Vrije Universiteit Medisch Centrum /ID# 225608, Amsterdam, , Netherlands
Onze Lieve Vrouwe Gasthuis /ID# 229761, Amsterdam, , Netherlands
Haaglanden Medisch Centrum /ID# 229686, Den Haag, , Netherlands
Deventer Ziekenhuis /ID# 229937, Deventer, , Netherlands
Catharina Ziekenhuis /ID# 230465, Eindhoven, , Netherlands
Maxima Medisch Centrum /ID# 225603, Eindhoven, , Netherlands
Medisch Spectrum Twente /ID# 225610, Enschede, , Netherlands
Universitair Medisch Centrum Groningen /ID# 225602, Groningen, , Netherlands
Medisch Centrum Leeuwarden /ID# 225605, Leeuwarden, , Netherlands
Leids Universitair Medisch Centrum /ID# 225606, Leiden, , Netherlands
Maastricht Universitair Medisch Centrum /ID# 225607, Maastricht, , Netherlands
St. Antonius Ziekenhuis /ID# 229901, Nieuwegein, , Netherlands
Canisius-Wilhelmina Ziekenhuis /ID# 231291, Nijmegen, , Netherlands
Jeroen Bosch Ziekenhuis /ID# 229765, S Hertogenbosch, , Netherlands
Elisabeth Tweesteden Ziekenhuis /ID# 229773, Tilburg, , Netherlands
Diakonessenhuis /ID# 251793, Utrecht, , Netherlands
North Shore Hospital /ID# 250992, Takapuna, Auckland, New Zealand
Christchurch Hospital /ID# 250993, Christchurch, Canterbury, New Zealand
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723, Slupsk, Pomorskie, Poland
Swietokrzyskie Centrum Onkologii /ID# 225986, Kielce, Swietokrzyskie, Poland
SP ZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985, Olsztyn, Warminsko-mazurskie, Poland
ARS-MEDICAL Sp. z o.o. /ID# 225848, Pila, Wielkopolskie, Poland
Centrum Medyczne Promed - Skorzewo /ID# 227236, Skorzewo, Wielkopolskie, Poland
2CA-Braga, Hospital de Braga /ID# 249112, Braga, , Portugal
IPO Lisboa FG, EPE /ID# 249109, Lisboa, , Portugal
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 249111, Lisboa, , Portugal
IPO Porto FG, EPE /ID# 249110, Porto, , Portugal
Hematology and Oncology Institute /ID# 230054, Manati, , Puerto Rico
Pan American Center for Oncology Trials, LLC /ID# 230052, Rio Piedras, , Puerto Rico
Narodny onkologicky ustav /ID# 238847, Bratislava, Nitriansky Kraj, Slovakia
Wits Clinical Research /ID# 227799, Johannesburg, Gauteng, South Africa
Wits Clinical Research /ID# 227803, Johannesburg, Gauteng, South Africa
Alberts Cellular Therapy /ID# 227798, Pretoria, Gauteng, South Africa
Haemalife Inc. /ID# 243391, Kuilsrivier, Western Cape, South Africa
Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063, Badalona, Barcelona, Spain
Instituto Catalan de Oncologia (ICO) L'Hospitalet /ID# 227393, Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Reina Sofia /ID# 225806, Córdoba, Cordoba, Spain
Hospital Clinico Universitario Virgen de la Arrixaca /ID# 255381, El Palmar, Murcia, Spain
Clinica Universidad de Navarra - Pamplona /ID# 225809, Pamplona, Navarra, Spain
Hospital Parc de Salut del Mar /ID# 225810, Barcelona, , Spain
Hospital Universitario Vall d'Hebron /ID# 225811, Barcelona, , Spain
Hospital Clinic de Barcelona /ID# 226651, Barcelona, , Spain
Hospital Santa Creu i Sant Pau /ID# 225813, Barcelona, , Spain
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228, Madrid, , Spain
Hospital Universitario Infanta Leonor /ID# 225816, Madrid, , Spain
MD Anderson Madrid /ID# 225817, Madrid, , Spain
Hospital Universitario Ramon y Cajal /ID# 241750, Madrid, , Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 225804, Madrid, , Spain
Hospital Universitario 12 de Octubre /ID# 225815, Madrid, , Spain
Hospital Clinico Universitario de Valencia /ID# 225818, Valencia, , Spain
Skane University Hospital Lund /ID# 227285, Lund, Skane Lan, Sweden
Sodra Alvsborgs sjukhus /ID# 228885, Boras, Vastra Gotalands Lan, Sweden
Sahlgrenska Universitetssjukhuset /ID# 250089, Göteborg, Vastra Gotalands Lan, Sweden
Linkoping University Hospital /ID# 233521, Linkoping, , Sweden
Karolinska Universitetssjukhuset Solna /ID# 229284, Solna, , Sweden
Kantonsspital Aarau AG /ID# 229112, Aarau, Aargau, Switzerland
Spital Thun /ID# 229499, Thun, Bern, Switzerland
KSW Kantonsspital Winterthur /ID# 241631, Winterthur, Zuerich, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 226670, Kaohsiung City, Kaohsiung, Taiwan
China Medical University Hospital /ID# 226188, Taichung, , Taiwan
Taichung Veterans General Hospital /ID# 226674, Taichung, , Taiwan
National Cheng Kung University Hospital /ID# 226671, Tainan, , Taiwan
Anadolu Saglik Merkezi /ID# 225777, Dilovası, Kocaeli, Turkey
Ankara Universitesi Fakultesi /ID# 227331, Ankara, , Turkey
Inonu University Medical Faculty /ID# 226572, Malatya, , Turkey
Ondokuz Mayis Universitesi Tip /ID# 251247, Samsun, , Turkey
Karadeniz University /ID# 226573, Trabzon, , Turkey
Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921, Yuregir, , Turkey
Imperial College London - St Mary's Hospital /ID# 242215, London, London, City Of, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692, Norwich, Norfolk, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 229197, Birmingham, , United Kingdom
Name: ABBVIE INC.
Affiliation: AbbVie
Role: STUDY_DIRECTOR