Spots Global Cancer Trial Database for Single-Cell Map of Immune and Lymphoma Cells in B-cell Non-Hodgkin's Lymphoma

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Trial Identification

Brief Title: Single-Cell Map of Immune and Lymphoma Cells in B-cell Non-Hodgkin's Lymphoma

Official Title: Single-Cell Map of Immune and Lymphoma Cells in B-cell Non-Hodgkin's Lymphoma

Study ID: NCT04696692

Conditions

Diffuse Large B-cell Lymphoma

Interventions

Patient with histologically confirmed diffuse large B-cell lymphoma with a planned first line treatment by R-CHOP.

Study Description

Brief Summary: This trial is a translational, prospective, open-label, monocentric research. The study will be conducted in a population of 60 patients with diffuse large B-cell lymphoma (DLBCL) for whom first-line treatment with R-CHOP is planned as part of their standard of care. SIMILY program aims at identifying biomarkers and/or molecular signatures related to immuno-phenotypic and -genotypic characteristics of the tumor and immune microenvironment, at the time of diagnosis, during R-CHOP, and at 24 months or time of progression. Each patient will be followed during 2 years.

Detailed Description: