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Brief Title: A Study of Navitoclax in Addition to Bendamustine and Rituximab in Patients With Relapsed Diffuse Large B-Cell Lymphoma (NAVIGATE)
Official Title: A Phase II, Multicenter, Randomized, Controlled, Open-Label Study of Bendamustine + Rituximab With or Without Navitoclax in Patients With Relapsed Diffuse Large B-Cell Lymphoma
Study ID: NCT01423539
Brief Summary: This randomized, open-label, multicenter study will evaluate the efficacy and safety of navitoclax in addition to bendamustine and rituximab in patients with relapsed diffuse large B-cell lymphoma. Patients will be randomized to receive navitoclax in addition to bendamustine and rituximab or bendamustine and rituximab alone for 6 cycles.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, Fountain Valley, California, United States
, Hudson, Florida, United States
, Lawrenceville, Georgia, United States
, Centralia, Illinois, United States
, Harvey, Illinois, United States
, Terre Haute, Indiana, United States
, Hazard, Kentucky, United States
, Paducah, Kentucky, United States
, Rockville, Maryland, United States
, Jefferson City, Missouri, United States
, Great Falls, Montana, United States
, Newark, Ohio, United States
, Nashville, Tennessee, United States
Name: Clinical Trials
Affiliation: Genentech, Inc.
Role: STUDY_DIRECTOR