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Spots Global Cancer Trial Database for A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma

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Trial Identification

Brief Title: A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma

Official Title: A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma

Study ID: NCT03579082

Interventions

Decitabine

Study Description

Brief Summary: To explore the safety, tolerability and clinical effects of decitabine combined with R±DHAP for patients with replase and refractory Diffuse Large B cell lymphoma.

Detailed Description: This is a randomized,controlled,prospective,open,multi-center clinical trial,amied to evaluate the safety, tolerability,and efficacy of decitabine combined with R±DHAP in replase and refractory Diffuse Large B cell lymphoma.A total of 60 patients are planned to be enrolled into the study.Patients with diagnosis of replase and refractory Diffuse Large B cell lymphoma will be into two groups,and be treated with decitabine pluse R±DHAP or only R±DHAP,respectively.The primary end points are objective responder rate(ORR) and time to progression(TTP) and the secondary end points include overall survival(OS) and progression free survival(PFS).

Eligibility

Minimum Age: 14 Years

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Oncology Department of The First Affilliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

Contact Details

Name: Mingzhi Zhang

Affiliation: The first affilliated hospital of zhengzhou university

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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