Spots Global Cancer Trial Database for Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer
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Trial Identification
Brief Title: Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer
Official Title: A PHASE 2, NON RANDOMIZED, OPEN LABEL, SINGLE ARM, MULTI CENTER STUDY OF TALAZOPARIB FOR NEOADJUVANT TREATMENT OF GERMLINE BRCA1/2 MUTATION PATIENTS WITH EARLY HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 NEGATIVE BREAST CANCER
Study ID: NCT03499353
Conditions
Interventions
Study Description
Brief Summary: A PHASE 2, NON RANDOMIZED, OPEN LABEL, SINGLE ARM, MULTI CENTER STUDY OF TALAZOPARIB FOR NEOADJUVANT TREATMENT OF GERMLINE BRCA1/2 MUTATION PATIENTS WITH EARLY HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 NEGATIVE BREAST CANCER
Detailed Description: TALAZOPARIB (PARP INHIBITOR) FOR NEOADJUVANT TREATMENT OF GERMLINE BRCA1/2 MUTATION PATIENTS WITH EARLY HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 NEGATIVE BREAST CANCER. THIS IS A MONOTHERAPY TREATMENT FOR 24 WKS FOLLOWED BY SURGERY TO EVALUATE PATHOLOGICAL COMPLETE RESPONSE.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Banner Gateway Medical Center, Gilbert, Arizona, United States
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
Highlands Oncology Group, Fayetteville, Arkansas, United States
Highlands Oncology Group, Rogers, Arkansas, United States
PMK Medical Group Inc., dba Ventura County Hematology Oncology Specialists, Camarillo, California, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California, United States
City of Hope Investigational Drug Services (IDS), Duarte, California, United States
The Oncology Institute of Hope & Innovation, Glendale, California, United States
Glendale Adventist Medical Center, Glendale, California, United States
The Oncology Institute of Hope & Innovation, Long Beach, California, United States
UC Irvine Health, Orange, California, United States
UC Irvine Medical Center, Orange, California, United States
PMK Medical Group Inc., dba Ventura County Hematology Oncology Specialists, Oxnard, California, United States
Emad Ibrahim, MD, INC., Redlands, California, United States
The Oncology Institute of Hope & Innovation, Santa Ana, California, United States
Stanford Cancer Institute, Stanford, California, United States
Stanford Hospital and Clinics, Stanford, California, United States
Stanford Women's Cancer Center, Stanford, California, United States
PMK Medical Group Inc., dba Ventura County Hematology Oncology Specialists, Ventura, California, United States
The Oncology Institute of Hope & Innovation, West Covina, California, United States
The Oncology Institute of Hope & Innovation, Whittier, California, United States
ICRI, Whittier, California, United States
Rocky Mountain Cancer Centers, Aurora, Colorado, United States
Rocky Mountain Cancer Centers, Boulder, Colorado, United States
Rocky Mountain Cancer Centers, Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers, Denver, Colorado, United States
Rocky Mountain Cancer Centers, Denver, Colorado, United States
Rocky Mountain Cancer Centers, Englewood, Colorado, United States
Rocky Mountain Cancer Centers, Lakewood, Colorado, United States
Rocky Mountain Cancer Centers, Littleton, Colorado, United States
Rocky Mountain Cancer Centers, Lone Tree, Colorado, United States
Rocky Mountain Cancer Centers, Longmont, Colorado, United States
Rocky Mountain Cancer Centers, Parker, Colorado, United States
Rocky Mountain Cancer Centers, Pueblo, Colorado, United States
Rocky Mountain Cancer Centers, Thornton, Colorado, United States
Innovative Medical Research of South Florida, Inc, Aventura, Florida, United States
Grady Health System, Atlanta, Georgia, United States
Emory University Hospital Midtown, Atlanta, Georgia, United States
Emory University Hospital, Atlanta, Georgia, United States
The Emory Clinic, Atlanta, Georgia, United States
Winship Cancer Institute, Atlanta, Georgia, United States
Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
Rush University Medical Center, Professional Office Building Infusion Pharmacy, Chicago, Illinois, United States
Rush University Medical Center, Chicago, Illinois, United States
Rush Oak Park Hospital, Oak Park, Illinois, United States
University of Mississippi Medical Center, Jackson, Mississippi, United States
Summit Medical Group, Berkeley Heights, New Jersey, United States
Summit Medical Group PA, Florham Park, New Jersey, United States
St. Luke's Hospital - Warren Campus, Phillipsburg, New Jersey, United States
St. Luke's Warren Physician Group, Phillipsburg, New Jersey, United States
Northwest Cancer Specialists, P.C., Portland, Oregon, United States
Northwest Cancer Specialists, P.C., Portland, Oregon, United States
Northwest Cancer Specialists, P.C., Tigard, Oregon, United States
St. Luke's Hematology Oncology Specialists, Allentown, Pennsylvania, United States
St. Luke's Hospital - Allentown Campus, Allentown, Pennsylvania, United States
St. Luke's Hematology Oncology Specialists, Bethlehem, Pennsylvania, United States
St. Luke's Hospital - Bethlehem Campus, Bethlehem, Pennsylvania, United States
St. Luke's Hospital - Miners Campus, Coaldale, Pennsylvania, United States
St Luke's Hospital - Anderson Campus, Easton, Pennsylvania, United States
St. Luke's Hospital - Anderson Campus, Easton, Pennsylvania, United States
UPMC Hillman Cancer Center Mountainview Arnold Palmer Pavilion, Greensburg, Pennsylvania, United States
UPMC Cancer Centers East Oxford Drive, Monroeville, Pennsylvania, United States
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center North Hills at Passavant, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center UPMC Passavant, Pittsburgh, Pennsylvania, United States
St. Luke's Hospital - Quakertown Campus, Quakertown, Pennsylvania, United States
St. Luke's Hospital - Monroe Campus, Stroudsburg, Pennsylvania, United States
UPMC Hillman Cancer Center Uniontown, Uniontown, Pennsylvania, United States
UPMC Hillman Cancer Center Washington, Washington, Pennsylvania, United States
Charleston Hematology Oncology Associates, PA, Charleston, South Carolina, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Avera Specialty Hospital, Sioux Falls, South Dakota, United States
Brig Center for Cancer Care and Survivorship, Knoxville, Tennessee, United States
Baptist Cancer Center, Memphis, Tennessee, United States
Texas Oncology - Allen, Allen, Texas, United States
Texas Oncology - Austin Midtown, Austin, Texas, United States
Texas Oncology-Austin Central, Austin, Texas, United States
Texas Oncology - South Austin, Austin, Texas, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
Texas Oncology-Denton South, Denton, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
U.T. MD Anderson Cancer Center, Investigational Pharmacy Services - Unit 376, Houston, Texas, United States
U.T. MD Anderson Cancer Center, Houston, Texas, United States
US Oncology Investigational Products Center (IPC), Irving, Texas, United States
Texas Oncology - McKinney, McKinney, Texas, United States
Texas Oncology - Round Rock, Round Rock, Texas, United States
Virginia Oncology Associates, Chesapeake, Virginia, United States
Virginia Oncology Associates, Hampton, Virginia, United States
Virginia Oncology Associates, Newport News, Virginia, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Virginia Oncology Associates, Virginia Beach, Virginia, United States
Northwest Cancer Specialists, P.C., Vancouver, Washington, United States
Northwest Cancer Specialists, P.C., Vancouver, Washington, United States
University of Wisconsin Clinical Science Center, Madison, Wisconsin, United States
UW Health University Hospital - Pharmaceutical Research Center, Madison, Wisconsin, United States
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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