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Brief Title: EBV-Tscm Cytotoxic T Cells (CTLs) for EBV- Driven Lymphomas/ Diseases
Official Title: Epstein-Barr Virus (EBV) -Specific T Memory Stem Cell (Tscm) Therapy to Treat EBV- Driven Lymphomas/ Diseases
Study ID: NCT05688241
Brief Summary: In this multi-center open-label, non-randomized phase I/II intervention study three consecutive doses of donor-derived EBV Tscm-CTLs will be administered to 10 patients with treatment-refractory EBV lymphoma, diseases or PTLDs. EBV Tscm-CTLs will derive from hematopoietic cell transplant (HCT) or third-party donors.
Detailed Description: Epstein Barr virus (EBV)-driven lymphomas and diseases are associated with poor prognosis. EBV proteins are recognized by T cells providing opportunities for EBV-specific T-cell therapy. Recent findings show that early differentiated T cells (T memory stem cells, Tscm) improve the prognosis in chronic viral diseases and are associated with effective tumor cell killing in melanoma patients. Tscm might be superior to highly differentiated T cells because of their longevity, robust proliferative potential, and capacity to reconstitute a wide T-cell receptor (TCR) diversity. This project will test the hypothesis that Tscm are efficacious for EBV-specific T-cell therapy. Clinical-grade enriched EBV-specific Tscm-CTLs will be prepared and used to treat patients with primary EBV lymphomas, diseases or post-transplant lymphoproliferative disease (PTLD) with limited other treatment options.
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University Hospital Basel, Klinik für Infektiologie und Spitalhygiene, Basel, , Switzerland
Universitäts-Kinderspital beider Basel (UKBB), Basel, , Switzerland
Universitätsspital Bern, Klinik für Infektiologie, Bern, , Switzerland
Hôpitaux Universitaires de Genève, Hôpital des Enfants, Genève, , Switzerland
Hôpitaux Universitaires de Genève, Service d'Hématologie, Genève, , Switzerland
Centre hospitalier universitaire vaudois, Service et Laboratoire central d'hématologie, Lausanne, , Switzerland
Kinderspital Zürich, Zürich, , Switzerland
University Hospital Zurich, Hämatologie, Zürich, , Switzerland
Name: Nina Khanna, Prof. Dr. med.
Affiliation: Klinik für Infektiologie und Spitalhygiene, University Hospital of Basel
Role: PRINCIPAL_INVESTIGATOR