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Spots Global Cancer Trial Database for Analysis of miRNA Expression in Endometrial Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Analysis of miRNA Expression in Endometrial Cancer

Official Title: Identification of miRNAs in Endometrial Cancer as Novel Diagnostic and Prognostic Biomarkers

Study ID: NCT04845425

Interventions

Study Description

Brief Summary: The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) the copy-number high subtype, with p53 abnormal/mutated features (p53abn); (iv) the copy-number low subtype, known as No Specific Molecular Profile (NSMP). Although the prognostic value of TCGA molecular classification, NSMP carcinomas present a wide variability in molecular alterations and biological aggressiveness. Given that the study aims to evaluate the miRNA expression profile to identify novel potential biomarkers to better stratify the EC patients, taking into account the molecular status

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

IRCCS- Azienda Ospedaliera-Universitaria di Bologna, Bologna, Bo, Italy

Contact Details

Name: Anna Myriam Perrone

Affiliation: IRCCS- Azienda Ospedaliera-Universitaria di Bologna

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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