Spots Global Cancer Trial Database for Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line
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Trial Identification
Brief Title: Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line
Official Title: Randomized Phase III Trial in MMR Deficient Endometrial Cancer Patients Comparing Chemotherapy Alone Versus Dostarlimab in First Line Advanced/Metastatic Setting
Study ID: NCT05201547
Conditions
Study Description
Brief Summary: Phase 3, randomized, multicentre study to evaluate the efficacy and safety of dostarlimab versus carboplatin-paclitaxel in patients with MMR deficient relapse or advanced endometrial cancer.
Detailed Description: Phase III, randomized, open label, multi-centre study. Randomization on a 1:1 ratio, stratification performed according to: * Prior adjuvant chemotherapy (yes or no) * Prior pelvic radiotherapy (yes or no) * Disease status: newly diagnosed advanced / metastatic disease versus relapse
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Canberra Hospital, Garran, , Australia
Calvary Mater Newcastle, Waratah, , Australia
Princess Margaret Cancer Centre, Toronto, , Canada
ICO Paul Papin, Angers, , France
Institut Sainte Catherine, Avignon, , France
CHRU Jean Minjoz, Besançon, , France
Institut Bergonié, Bordeaux, , France
CHU Brest, Brest, , France
Centre François Baclesse, Caen, , France
ROC 37, Chambray-lĂšs-Tours, , France
Centre Jean Perrin, Clermont-Ferrand, , France
Centre Hospitalier Intercommunal de Créteil, Créteil, , France
Centre Georges François Leclerc, Dijon, , France
CHU de Dijon, Dijon, , France
Clinique Victor Hugo, Le Mans, , France
Centre Oscar Lambret, Lille, , France
Centre Hospitalier Lyon Sud, Lyon, , France
Centre LĂ©on BĂ©rard, Lyon, , France
APHM - HĂŽpital de la Timone, Marseille, , France
Institut Paoli Calmettes, Marseille, , France
HĂŽpital Saint-Joseph, Marseille, , France
HĂŽpital de Mont-de-Marsan, Mont de Marsan, , France
ICM Val d'Aurelle, Montpellier, , France
Centre Azuréen de Cancérologie, Mougins, , France
MĂ©dipĂŽle de NANCY SAS, Nancy, , France
HÎpital Privé du Confluent S.A.S., Nantes, , France
Centre Antoine Lacassagne, Nice, , France
Institut de cancérologie du gard, Nßmes, , France
Centre Hospitalier Régional, Orléans, , France
Institut Curie, Paris, , France
AP-HP HĂŽpital PitiĂ©-SalpĂȘtriĂšre, Paris, , France
HĂŽpital Cochin, Paris, , France
Groupe Hospitalier Diaconesses-Croix Saint-Simon, Paris, , France
HÎpital Européen Georges Pompidou, Paris, , France
Institut Mutualiste Montsouris, Paris, , France
Centre CARIO - HPCA, Plérin, , France
CHU de Poitiers - HÎpital de la Milétrie, Poitiers, , France
CHI de Cornouaille, Quimper, , France
Institut Jean Godinot, Reims, , France
Centre EugĂšne Marquis, Rennes, , France
Centre Henri Becquerel, Rouen, , France
ICO - Centre René Gauducheau, Saint-Herblain, , France
CHU Saint-Etienne - PĂŽle de CancĂ©rologie, Saint-Ătienne, , France
Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg, , France
Institut Claudius RĂ©gaud, Toulouse, , France
CHU Bretonneau, Tours, , France
ICL - Centre Alexis Vautrin, VandĆuvre-lĂšs-Nancy, , France
Institut Gustave Roussy, Villejuif, , France
National University Hospital (NUH), Singapore, , Singapore
National Cancer Centre Singapore (NCCS), Singapore, , Singapore
Hospital General Universitario de Elche, Elche, Alicante, Spain
Hospital Germans Trias i Pujol / ICO Badalona, Badalona, , Spain
Hospital Universitario Reina Sofia, CĂłrdoba, , Spain
Hospital Universitario de LeĂłn, LeĂłn, , Spain
Hospital Son LlĂĄtzer, Palma De Mallorca, , Spain
Hospital Universitario Son Espases, Palma, , Spain
Hospital ClĂnico Universitario Santiago de Compostela, Santiago De Compostela, , Spain
Hospital Universitario y Politécnico La Fe, Valencia, , Spain
Hospital Universitario Miguel Servet, Zaragoza, , Spain
Contact Details
Name: Florence JOLY, Pr
Affiliation: Centre François Baclesse
Role: PRINCIPAL_INVESTIGATOR
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