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Brief Title: Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Official Title: A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Adjuvant Chemotherapy With or Without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative Intent (KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Study ID: NCT04634877
Brief Summary: The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
University of Alabama - Birmingham ( Site 3061), Birmingham, Alabama, United States
University of South Alabama, Mitchell Cancer Institute ( Site 3058), Mobile, Alabama, United States
HonorHealth Research Institute - Biltmore ( Site 3043), Phoenix, Arizona, United States
Arizona Oncology Associates PC- HOPE ( Site 3049), Tucson, Arizona, United States
UCSD Moores Cancer Center ( Site 3053), La Jolla, California, United States
University Of Colorado ( Site 3051), Aurora, Colorado, United States
Smilow Cancer Hospital at Yale New Haven ( Site 3070), New Haven, Connecticut, United States
Mount Sinai Cancer Center ( Site 3081), Miami Beach, Florida, United States
Northside Hospital ( Site 3036), Atlanta, Georgia, United States
Northwestern Memorial Hospital ( Site 3044), Chicago, Illinois, United States
Parkview Cancer Institute ( Site 3067), Fort Wayne, Indiana, United States
Indiana University Melvin and Bren Simon Cancer Center ( Site 3071), Indianapolis, Indiana, United States
University of Iowa Hospital and Clinics ( Site 3046), Iowa City, Iowa, United States
Norton Cancer Institute - St. Matthews ( Site 3056), Louisville, Kentucky, United States
WK Physicians Network/Gynecologic Oncology Associates ( Site 3047), Shreveport, Louisiana, United States
University of Massachusetts Medical School ( Site 3037), Worcester, Massachusetts, United States
Montefiore Medical Center ( Site 3065), Bronx, New York, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 3076), Mineola, New York, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 3042), New York, New York, United States
Duke Cancer Center ( Site 3072), Durham, North Carolina, United States
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3080), Fargo, North Dakota, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio, United States
Legacy Good Samaritan Medical Center ( Site 3033), Portland, Oregon, United States
Sidney Kimmel Cancer Center - Jefferson Health ( Site 3078), Philadelphia, Pennsylvania, United States
AHN West Penn Hospital ( Site 3060), Pittsburgh, Pennsylvania, United States
Abington Hospital - Asplundh Cancer Center ( Site 3073), Willow Grove, Pennsylvania, United States
Sanford Gynecology Oncology ( Site 3045), Sioux Falls, South Dakota, United States
UT Southwestern Medical Center ( Site 3063), Dallas, Texas, United States
VCU Massey Cancer Center ( Site 3068), Richmond, Virginia, United States
Centro de Oncología e Investigación de Buenos Aires ( Site 1005), Berazategui, Buenos Aires, Argentina
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 1006), Caba, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 1003), Mar del Plata, Buenos Aires, Argentina
Hospital Britanico de Buenos Aires ( Site 1002), Buenos Aires, Caba, Argentina
Instituto de Oncologia de Rosario ( Site 1004), Rosario, Santa Fe, Argentina
IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 1010), Buenos Aires, , Argentina
Hospital Aleman ( Site 1001), Buenos Aires, , Argentina
CEMIC ( Site 1009), Buenos Aires, , Argentina
Centro Oncologico Riojano Integral ( Site 1007), La Rioja, , Argentina
Medizinische Universitat Graz ( Site 2004), Graz, Steiermark, Austria
Medizinische Universitaet Innsbruck ( Site 2001), Innsbruck, Tirol, Austria
Saint-Luc UCL ( Site 2042), Bruxelles, Bruxelles-Capitale, Region De, Belgium
C.I.U. Hopital Ambroise Pare ( Site 2039), Mons, Hainaut, Belgium
CHR Verviers ( Site 2035), Verviers, Liege, Belgium
OLV Ziekenhuis ( Site 2038), Aalst, Oost-Vlaanderen, Belgium
AZ Maria Middelares Gent ( Site 2032), Gent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Gent ( Site 2037), Gent, Oost-Vlaanderen, Belgium
AZ Nikolaas ( Site 2031), Sint-Niklaas, Oost-Vlaanderen, Belgium
UZ Leuven ( Site 2040), Leuven, Vlaams-Brabant, Belgium
AZ Groeninge ( Site 2036), Kortrijk, West-Vlaanderen, Belgium
CHC - Groupe Sante ( Site 2041), Liege, , Belgium
CHU Liege Sart-Tilman ( Site 2044), Liege, , Belgium
Tom Baker Cancer Centre ( Site 3007), Calgary, Alberta, Canada
Kingston Health Sciences Centre ( Site 3003), Kingston, Ontario, Canada
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 3006), Montreal, Quebec, Canada
McGill University Health Centre ( Site 3005), Montreal, Quebec, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3, Quebec City, Quebec, Canada
Centro Investigación del Cáncer James Lind ( Site 1061), Temuco, Araucania, Chile
Fundacion Arturo Lopez Perez FALP ( Site 1062), Santiago, Region M. De Santiago, Chile
Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063), Santiago, Region M. De Santiago, Chile
Bradfordhill-Clinical Area ( Site 1070), Santiago, Region M. De Santiago, Chile
Oncocentro ( Site 1065), Vina del Mar, Valparaiso, Chile
Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 4034), Hefei, Anhui, China
Beijing Cancer Hospital ( Site 4048), Beijing, Beijing, China
Peking Union Medical College Hospital ( Site 4036), Beijing, Beijing, China
Chongqing Cancer Hospital ( Site 4040), Chongqing, Chongqing, China
The First Affiliated Hospital of Xiamen University ( Site 4060), Xiamen, Fujian, China
The First Affiliated Hospital ( Site 4043), Guangzhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital ( Site 4049), Nanning, Guangxi, China
Harbin Medical University Cancer Hospital ( Site 4033), Harbin, Heilongjiang, China
Hubei Cancer Hospital ( Site 4059), Wuhan, Hubei, China
Xiangya Hospital Central-South University ( Site 4035), Changsha, Hunan, China
Hunan Cancer Hospital ( Site 4050), Changsha, Hunan, China
Nanjing Drum Tower Hospital ( Site 4037), Nanjing, Jiangsu, China
Jiangxi Maternal and Child Health Hospital ( Site 4051), Nanchang, Jiangxi, China
The First Bethune Hospital of Jilin University ( Site 4057), Changchun, Jilin, China
The First Affiliated Hospital of Xi an Jiaotong University ( Site 4045), XI An, Shaanxi, China
Obstetrics and Gynecology Hosp. Fudan University ( Site 4041), Shanghai, Shanghai, China
Shanghai Renji Hospital Affiliated to Jiao Tong University ( Site 4053), Shanghai, Shanghai, China
Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 4001), Shanghai, Shanghai, China
Sichuan Cancer Hospital ( Site 4039), Chengdu, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital ( Site 4054), Tianjin, Tianjin, China
Yunnan Province Cancer Hospital-Gynecology Department ( Site 4055), Kunming, Yunnan, China
The First Affiliated Hospital, Zhejiang University-Gynecology ( Site 4002), Hangzhou, Zhejiang, China
Women s Hospital School of Medicine Zhejiang University ( Site 4032), Hangzhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University ( Site 4056), Wenzhou, Zhejiang, China
Clínica Vida Fundación - Sede Poblado ( Site 1096), Medellin, Antioquia, Colombia
Instituto Nacional de Cancerología E.S.E ( Site 1094), Bogota, Distrito Capital De Bogota, Colombia
Instituto Cancerologico de Narino Ltda ( Site 1092), San Juan De Pasto, Narino, Colombia
Fundacion Valle del Lili ( Site 1093), Cali, Valle Del Cauca, Colombia
Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 2394), Brno, Brno-mesto, Czechia
Fakultni nemocnice Kralovske Vinohrady ( Site 2393), Praha, Praha 10, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 2391), Praha, Praha 2, Czechia
Fakultni nemocnice Olomouc ( Site 2392), Olomouc, , Czechia
Rigshospitalet University Hospital ( Site 2515), Copehagen, Hovedstaden, Denmark
Herlev Hospital ( Site 2514), Herlev, Hovedstaden, Denmark
Aalborg Universitetshospital ( Site 2511), Aalborg, Nordjylland, Denmark
Roskilde Sygehus ( Site 2513), Roskilde, Sjaelland, Denmark
Odense Universitetshospital ( Site 2512), Odense, Syddanmark, Denmark
Tampere University Hospital ( Site 2541), Tampere, Pirkanmaa, Finland
Kuopio University Hospital ( Site 2543), Kuopio, Pohjois-Savo, Finland
Turku University Hospital ( Site 2542), Turku, Varsinais-Suomi, Finland
Institut De Cancerologie De Lorraine ( Site 2072), Vandoeuvre les Nancy, Ain, France
Centre Antoine Lacassagne ( Site 2073), Nice, Alpes-Maritimes, France
Centre Francois Baclesse ( Site 2062), Caen, Calvados, France
Hôpital Privé Des Côtes d'Armor ( Site 2063), Plérin, Cotes-d Armor, France
CHU Besancon - Hopital Jean Minjoz ( Site 2068), Besancon, Doubs, France
Institut Bergonie ( Site 2067), Bordeaux, Gironde, France
Institut Universitaire du Cancer Toulouse - Oncopole ( Site 2065), Toulouse, Haute-Garonne, France
Institut Regional du Cancer de Montpellier - ICM ( Site 2069), Montpellier, Herault, France
Hopital Cochin ( Site 2070), Paris, Ile-de-France, France
Gustave Roussy ( Site 2071), Villejuif, Ile-de-France, France
Hopital prive du Confluent ( Site 2061), Nantes, Loire-Atlantique, France
Centre Hospitalier Lyon Sud ( Site 2064), Pierre Benite, Rhone, France
SLK-Kliniken Heilbronn GmbH ( Site 2116), Heilbronn, Baden-Wurttemberg, Germany
Klinikum Ludwigsburg ( Site 2111), Ludwigsburg, Baden-Wurttemberg, Germany
Universitaetsklinikum Tuebingen ( Site 2113), Tübingen, Baden-Wurttemberg, Germany
Medizinische Hochschule Hannover-Department of Obstetrics and Gynecology ( Site 2109), Hannover, Niedersachsen, Germany
Universitätsklinikum Bonn-Gynaecological oncology ( Site 2103), Bonn, Nordrhein-Westfalen, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2105), Essen, Nordrhein-Westfalen, Germany
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden, Sachsen, Germany
Universitätsklinikum Schleswig-Holstein ( Site 2101), Lübeck, Schleswig-Holstein, Germany
General Hospital of Patras. St Andrews ( Site 2421), Patras, Achaia, Greece
Geniko Panepistimako Nosokomeio ARETEIO ( Site 2423), Athens, Attiki, Greece
Perifereiako Geniko Nosokomeio ALEXANDRA ( Site 2425), Athens, Attiki, Greece
Athens University Hospital ATTIKON ( Site 2424), Chaidari, Attiki, Greece
Hospital Hygeia ( Site 2426), Marousi, Attiki, Greece
Euromedica General Clinic of Thessaloniki ( Site 2422), Thessaloniki, , Greece
Rambam Medical Center ( Site 2307), Haifa, , Israel
Edith Wolfson Medical Center ( Site 2306), Holon, , Israel
Hadassah Medical Center. Ein Kerem ( Site 2303), Jerusalem, , Israel
Rabin Medical Center ( Site 2305), Petah Tikva, , Israel
Chaim Sheba Medical Center ( Site 2301), Ramat Gan, , Israel
Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 2121), Roma, Abruzzo, Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 2124), Roma, Lazio, Italy
Istituto di Candiolo - IRCCS ( Site 2125), Candiolo, Piemonte, Italy
Azienda Ospedaliera Spedali Civili di Brescia ( Site 2135), Brescia, , Italy
IRCCS Ospedale San Raffaele ( Site 2130), Milano, , Italy
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2122), Milano, , Italy
Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 2132), Milano, , Italy
Azienda Ospedaliera Universitaria Federico II ( Site 2123), Napoli, , Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2127), Napoli, , Italy
Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 2134), Padova, , Italy
Aichi Cancer Center Hospital ( Site 4190), Nagoya, Aichi, Japan
National Cancer Center Hospital East ( Site 4197), Kashiwa, Chiba, Japan
National Hospital Organization Shikoku Cancer Center ( Site 4181), Matsuyama, Ehime, Japan
Ehime University Hospital ( Site 4187), Toon, Ehime, Japan
Kurume University Hospital ( Site 4186), Kurume, Fukuoka, Japan
Gunma Prefectural Cancer Center ( Site 4183), Ota, Gunma, Japan
Hokkaido University Hospital ( Site 4194), Sapporo, Hokkaido, Japan
Hyogo Cancer Center ( Site 4195), Akashi, Hyogo, Japan
Iwate Medical University Hospital ( Site 4189), Shiwa-gun, Iwate, Japan
University of the Ryukyus Hospital ( Site 4184), Nakagami-gun, Okinawa, Japan
Saitama Medical University International Medical Center ( Site 4182), Hidaka, Saitama, Japan
Shizuoka Cancer Center Hospital and Research Institute ( Site 4192), Sunto-gun, Shizuoka, Japan
National Hospital Organization Kyushu Cancer Center ( Site 4193), Fukuoka, , Japan
Niigata Cancer Center Hospital ( Site 4185), Niigata, , Japan
Osaka International Cancer Institute ( Site 4188), Osaka, , Japan
The Cancer Institute Hospital of JFCR ( Site 4196), Tokyo, , Japan
Keio University Hospital ( Site 4191), Tokyo, , Japan
National Cancer Center ( Site 4065), Goyang-si, Kyonggi-do, Korea, Republic of
Seoul National University Bundang Hospital ( Site 4063), Seongnam-si, Kyonggi-do, Korea, Republic of
Severance Hospital Yonsei University Health System ( Site 4062), Seoul, , Korea, Republic of
Asan Medical Center ( Site 4061), Seoul, , Korea, Republic of
Samsung Medical Center ( Site 4064), Seoul, , Korea, Republic of
Investigacion Onco Farmaceutica S de RL de CV ( Site 1127), La Paz, Baja California Sur, Mexico
Hospital San Lucas Cardiologica del Sureste ( Site 1122), Tuxtla Gutierrez, Chiapas, Mexico
Instituto Nacional de Cancerologia ( Site 1124), Cdmx, Distrito Federal, Mexico
Christus Muguerza Clinica Vidriera ( Site 1125), Monterrey, Nuevo Leon, Mexico
I Can Oncology Center SA de CV ( Site 1126), Monterrey, Nuevo Leon, Mexico
Hospital Angeles Roma ( Site 1123), Ciudad de Mexico, , Mexico
Centro Oncologico Internacional. SEDNA ( Site 1121), Mexico City, , Mexico
University Hospital of North Norway ( Site 2153), Tromso, Troms, Norway
Soerlandet sykehus HF Kristiansand ( Site 2152), Kristiansand, Vest-Agder, Norway
Oslo Universitetssykehus Radiumhospitalet ( Site 2151), Oslo, , Norway
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2487), Siedlce, Mazowieckie, Poland
Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 2481), Warszawa, Mazowieckie, Poland
Bialostockie Centrum Onkologii ( Site 2483), Bialystok, Podlaskie, Poland
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2482), Gliwice, Slaskie, Poland
Swietokrzyskie Centrum Onkologii SPZOZ ( Site 2485), Kielce, Swietokrzyskie, Poland
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2486), Olsztyn, Warminsko-mazurskie, Poland
Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 2484), Poznan, Wielkopolskie, Poland
Arkhangelsk Clinical Oncological Dispensary ( Site 2637), Arkhangelsk, Arkhangel Skaya Oblast, Russian Federation
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 2645), Ufa, Baskortostan, Respublika, Russian Federation
Chelyabinsk Regional Clinical Center Oncology and Nuclear Medicine ( Site 2644), Chelyabinsk, Chelyabinskaya Oblast, Russian Federation
Krasnoyarsk Regional Clinical oncology dispensary ( Site 2643), Krasnoyarsk, Krasnoyarskiy Kray, Russian Federation
National Research Ogarev Mordovia State University ( Site 2648), Saransk, Mordoviya, Respublika, Russian Federation
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 2634), Moscow, Moskva, Russian Federation
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2631), Moscow, Moskva, Russian Federation
Nizhegorodsky Regional Oncology Dispensary-chemotherapy department (Branch№1) ( Site 2639), Nizhniy Novgorod, Nizhegorodskaya Oblast, Russian Federation
Samara Regional Clinical Oncology Center-Chemotherapy Dapartment ( Site 2649), Samara, Samarskaya Oblast, Russian Federation
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2636), Saint-Petersburg, Sankt-Peterburg, Russian Federation
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2646), Kazan, Tatarstan, Respublika, Russian Federation
Tomsk Scientific Research Institute of Oncology-Chemotherapy ( Site 2638), Tomsk, Tomskaya Oblast, Russian Federation
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2641), Yaroslavl, Yaroslavskaya Oblast, Russian Federation
Hospital Josep Trueta ( Site 2184), Girona, Gerona, Spain
Clinica Universitaria de Navarra ( Site 2181), Madrid, Madrid, Comunidad De, Spain
Hospital Vall D Hebron ( Site 2182), Barcelona, , Spain
Hospital Clinic i Provincial ( Site 2185), Barcelona, , Spain
Hospital Universitario Reina Sofia ( Site 2183), Cordoba, , Spain
Hospital Clinico San Carlos ( Site 2187), Madrid, , Spain
Hospital Universitario La Paz ( Site 2186), Madrid, , Spain
Universitetssjukhuset i Linkoping. ( Site 2222), Linkoping, Ostergotlands Lan, Sweden
Karolinska Universitetssjukhuset Solna ( Site 2220), Solna, Stockholms Lan, Sweden
Blod-och Tumorsjukdomar ( Site 2221), Uppsala, Uppsala Lan, Sweden
Changhua Christian Hospital ( Site 4095), Changhua, , Taiwan
Taichung Veterans General Hospital ( Site 4094), Taichung, , Taiwan
MacKay Memorial Hospital ( Site 4092), Taipei, , Taiwan
Taipei Veterans General Hospital ( Site 4093), Taipei, , Taiwan
Linkou Chang Gung Memorial Hospital ( Site 4091), Taoyuan, , Taiwan
Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2355), Adana, , Turkey
Cukurova Uni. Tip Fakultesi ( Site 2353), Adana, , Turkey
Baskent Universitesi Ankara Hastanesi ( Site 2354), Ankara, , Turkey
Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 2350), Ankara, , Turkey
Medipol Universite Hastanesi ( Site 2352), Istanbul, , Turkey
Ege University Medical Faculty ( Site 2351), Izmir, , Turkey
I.E.U. Medical Point Hastanesi ( Site 2356), Izmir, , Turkey
Chernihiv Medical Center of Modern Oncology ( Site 2368), Chernihiv, Chernihivska Oblast, Ukraine
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2366), Chernivtsi, Chernivetska Oblast, Ukraine
SO Grigoriev Institute for Medical Radiology and Oncology of NAMS of Ukraine ( Site 2363), Kharkiv, Kharkivska Oblast, Ukraine
MNE "Khmelnytskyi regional antitumor center" ( Site 2365), Khmelnitskyi, Khmelnytska Oblast, Ukraine
LISOD - Israeli Oncological Hospital MedX-ray International Group, LLC ( Site 2364), Kiev, Kyivska Oblast, Ukraine
Lviv State Regional Oncological Center ( Site 2361), Lviv, Lvivska Oblast, Ukraine
The Municipal Enterprise Volyn Regional Medical Oncology Centre ( Site 2362), Lutsk, Volynska Oblast, Ukraine
Bristol Haematology and Oncology Centre ( Site 2244), Bristol, Bristol, City Of, United Kingdom
Castle Hill Hospital-Academic Oncology ( Site 2252), Cottingham, East Riding Of Yorkshire, United Kingdom
Beatson West of Scotland Cancer Centre ( Site 2247), Glasgow, Glasgow City, United Kingdom
UCLH NHS Foundation Trust ( Site 2242), London, London, City Of, United Kingdom
Royal Marsden NHS Foundation Trust ( Site 2248), London, London, City Of, United Kingdom
Royal Marsden Hospital Sutton-Surrey ( Site 2241), Sutton, London, City Of, United Kingdom
Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 2249), Leicester, , United Kingdom
The Christie Hospital NHS Foundation Trust ( Site 2243), Manchester, , United Kingdom
Name: Medical Director
Affiliation: Merck Sharp & Dohme LLC
Role: STUDY_DIRECTOR