Spots Global Cancer Trial Database for Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action

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Trial Identification

Brief Title: Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action

Official Title: Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action

Study ID: NCT00942695

Conditions

Energy

Cardiovascular Disease

Cancer

Interventions

1.5PD

3.0PD

control

Study Description

Brief Summary: The objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.

Detailed Description: Previous studies have suggested that nut consumption imparts a variety of health benefits, including reduction of cardiovascular disease and improved satiety. However, studies of pistachios are extremely limited. The aim of this study is to determine the energy value of pistachios in the human diet and to probe mechanisms by which pistachios impart health benefits. The metabolizable energy value of pistachio nuts will be calculated based on the chemical composition and energy content of the consumed diet and excreta. This will provide a better estimate of the energy value of pistachios than simply calculating energy value based on Atwater factors. In addition to determining the energy value of pistachios, we will evaluate the effects of pistachio-rich diets on plasma phytonutrient levels and on gene expression changes to determine what protective mechanisms are activated by pistachio consumption.