Spots Global Cancer Trial Database for CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
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Trial Identification
Brief Title: CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
Official Title: Chimeric Antigen Receptor-Modified T Cells for EphA2 Positive Recurrent and Metastatic Malignant Glioma
Study ID: NCT02575261
Interventions
Study Description
Brief Summary: The purpose of this study is to evaluate the safety and effectiveness of CAR-T cell immunotherapy in treating with EphA2 positive malignant glioma patients.
Detailed Description: Chimeric antigen receptor (CAR) is a recombinant receptor with both antigen-binding and T cell activating functions. Chimeric antigen receptor T cell Immunotherapy has more advantages compared with conventional immunotherapy, especially in dealing with patients of hematologic malignancies and solid malignant tumors.This study design a novel specific Chimeric antigen receptor aiming at EphA2 antigen.After CAR-T cell infusion,At periodic intervals, the investigators will evaluate clinical symptoms Improved conditions of this disease.Through this study,the investigators will evaluate the safty and effectiveness of CAR-T cell immunotherapy in treating with EphA2 positive malignant glioma patients.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Central laboratory in Fuda cancer hospital, Guangzhou, Guangdong, China
Contact Details
Name: Lizhi Niu, PhD
Affiliation: Fuda Cancer Hospital
Role: STUDY_CHAIR
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