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Spots Global Cancer Trial Database for A Study to Find the MTD of SYN125 in People With Solid Tumors and the MTD of SYN125 With a Fixed Dose of SYN004 in People in Patients With Epithelial Cancers With EGFR Expressions

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Trial Identification

Brief Title: A Study to Find the MTD of SYN125 in People With Solid Tumors and the MTD of SYN125 With a Fixed Dose of SYN004 in People in Patients With Epithelial Cancers With EGFR Expressions

Official Title: A Phase 1 Dose Escalation Trial of SYN125 Single Agent in Solid Tumors and in Combination With Fixed Dose SYN004 in Patients With Epithelial Cancers With EGFR Expressions.

Study ID: NCT04363242

Interventions

SYN125
SYN004

Study Description

Brief Summary: A Phase 1 Dose Escalation Trial of SYN125 Single Agent in the Treatment of Solid Tumors and in Combination With Fixed Dose SYN004 in Patients With Cancer of the Internal or External Lining of the Body.

Detailed Description: Humans have an immune system that can protect and fight infections and abnormal cells. T-cells are a type of cell produced by the body that can attack and kill cancer cells. Unfortunately, many cancer cells have ways preventing T-cells from working properly. SYN125 and SYN004 can make T-cells work again. This is a study to find the maximum tolerated dose of SYN125 when it is used as a single treatment (Part A) for solid tumors, and when it is used as a combined treatment with a fixed dose of SYN004 (Part B), in patients with epithelial cancers with EGFR (epithelial growth factor receptor) expressions.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Kansas Cancer Center, Clinical Research Center, 4350 Shawnee Mission Parkway, MS 6004, Fairway, Kansas, United States

Henry Ford Health System, Henry Ford Hospital, Brownstown, Michigan, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

University of Oklahoma, Peggy and Charles Stephenson Cancer Center, 800 Northeast 10th Street, Oklahoma City, Oklahoma, United States

Contact Details

Name: Ding Wang, MD

Affiliation: Henry Ford Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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