Spots Global Cancer Trial Database for Comparison of Paclitaxel/Carboplatin and Lonafarnib to Paclitaxel/Carboplatin for First-line Treatment of Ovarian Cancer
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Trial Identification
Brief Title: Comparison of Paclitaxel/Carboplatin and Lonafarnib to Paclitaxel/Carboplatin for First-line Treatment of Ovarian Cancer
Official Title: An Open-label, Multicenter, Randomized Phase II Study to Compare the Effects of Paclitaxel/Carboplatin and Lonafarnib to Those of Paclitaxel/Carboplatin for First-line Treatment of Patients With Epithelial Ovarian Cancer FIGO Stages IIB-IV
Study ID: NCT00281515
Conditions
Interventions
Study Description
Brief Summary: The purpose of this study is to compare the effects of Paclitaxel/Carboplatin and Lonafarnib to those of Paclitaxel/Carboplatin in primary treatment of patients with epithelial ovarian cancer.
Detailed Description: Today the standard therapy for patients with advanced ovarian carcinoma is paclitaxel and carboplatin. Lonafarnib is a farnesyl transferase inhibitor (FTI) that is active against a broad spectrum of tumor cell lines in vitro and tumor xenografts in nude mice. Lonafarnib has single-agent antitumor activity as well as enhanced activity in combination with taxanes in a number of tumor cell lines and in vivo models.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
CharitÊ - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik fßr Frauenheilkunde, Berlin, , Germany
Klinikum Bremen Mitte, Frauenklinik, Bremen, , Germany
Carl-Gustav-Carus der TU Dresden, Universitäts-Frauenklinik, Dresden, , Germany
Ev. Krankenhaus, Frauenklinik, DĂźsseldorf, , Germany
Klinik fĂźr Frauenheilkunde der Univ. Erlangen, Erlangen, , Germany
Universitätsfrauenklinik, Essen, , Germany
Klinikum der Johann Wolfgang Goethe Universität, Klinik fßr Frauenheilkunde u. Geburtshilfe, Frankfurt, , Germany
Universitätsklinikum Freiburg, Frauenklinik, Freiburg, , Germany
Kreiskrankenhaus, Frauenklinik, Gifhorn, , Germany
Klinik u. Poliklinik fßr Gynäkologie und Geburtshilfe, Greifswald, , Germany
Medizinische Hochschule, Hannover, , Germany
St. Vincentius-Krankenhäuser, Karlsruhe, , Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik fßr Gynäkologie und Geburtshilfe, Kiel, , Germany
Klinik der Otto-von-Guericke Universität, Frauenklinik, Magdeburg, , Germany
Johannes-Gutenberg-Universität, Universitäts-Frauenklinik, Mainz, , Germany
Klinikum der Philipps-Universität Marburg, Klinik fßr Gynäkologie, Gynäkologische Endokrinologie, Marburg, , Germany
Klinikum GroĂhadern, Frauenklinik, MĂźnchen, , Germany
Klinikum rechts der Isar der TU MĂźnchen, MĂźnchen, , Germany
Elblandkliniken, Frauenklinik, Radebeul, , Germany
Klinikum SĂźdstadt, Rostock, , Germany
Universitäts-Frauenklinik, Tßbingen, , Germany
Universitätsfrauenklinik, Ulm, , Germany
Dr. Horst Schmidt Klinik, Gynäkologie u. Gynäkologische Onkologie, Wiesbaden, , Germany
Contact Details
Name: Werner Meier, Prof. Dr.
Affiliation: Ev. Krankenhaus, DĂźsseldorf, Germany
Role: PRINCIPAL_INVESTIGATOR
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