Spots Global Cancer Trial Database for AdvanTIG-203: Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
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Trial Identification
Brief Title: AdvanTIG-203: Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
Official Title: A Phase 2, Multicenter, Randomized, Placebo-Controlled Study to Compare the Efficacy of Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Plus Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) Versus Tislelizumab Plus Placebo as Second-Line Treatment in Patients With PD-L1 Tumor Area Positivity (TAP) ≥ 10% Unresectable, Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
Study ID: NCT04732494
Conditions
Study Description
Brief Summary: A study of tislelizumab (BGB-A317) plus ociperlimab versus tislelizumab plus placebo as second-line treatment in participants with programmed cell death protein-ligand 1 (PD-L1) tumor area positivity (TAP) ≥ 10% unresectable, locally advanced, recurrent or metastatic esophageal squamous cell carcinoma.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Anhui Provincial Cancer Hospital, Hefei, Anhui, China
Quanzhou First Hospital of Fujian Province, Quanzhou, Fujian, China
First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
Lanzhou University Second Hospital, Gansu, Gansu, China
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China
Meizhou Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong, China
Hainan Third People's Hospital, Sanya, Hainan, China
Nantong Tumor Hospital, Nantong, Jiangsu, China
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
Qinghai Provincial People's Hospital, Qinghai, Qinghai, China
Shandong Cancer Hospital, Jinan, Shandong, China
Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China
People's Hospital of Deyang City, Deyang, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, China
Yunnan Cancer Hospital, Kunming, Yunnan, China
First Affiliated Hospital of Kunming Medical University, Yunnan, Yunnan, China
Beijing Cancer Hospital, Beijing, , China
Beijing Friendship Hospital, Capital Medical University, Beijing, , China
Heping Hospital Affiliated to Changzhi Medical College, Changzhi, , China
The First People's Hospital of Changzhou, Changzhou, , China
Fujian Cancer Hospital, Fujian, , China
The First Affiliated Hospital of Fujian Medical University, Fujian, , China
Zhongshan Hospital Xiamen University, Fujian, , China
Cancer Hospital of Shantou University Medical College, Guangdong, , China
Nanfang Hospital of Southern Medical University, Guangdong, , China
Sun Yat-sen University Cancer Center, Guangdong, , China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, , China
The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, , China
Guangxi Medical University Affiliated Tumor Hospital, Guangxi, , China
Hainan General Hospital, Hainan, , China
Affiliated Hospital of Hebei University, Hebei, , China
The Second Hospital of Anhui Medical University, Hefei, , China
Harbin Medical University Cancer Hospital, Heilongjiang, , China
Henan Cancer Hospital, Henan, , China
The First Affiliated Hospital of Xinxiang Medical University, Henan, , China
The First Affiliated Hospital of Zhengzhou University, Henan, , China
Hubei Cancer Hospital, Hubei, , China
Xiangyang Central Hospital, Hubei, , China
Hunan Cancer Hospital, Hunan, , China
The First Affiliated Hospital of Nanchang University, Jiangxi, , China
The Second Affiliated Hospital of Nanchang University, Jiangxi, , China
Linyi Cancer Hospital, Shandong, , China
Weifang People's Hospital, Shandong, , China
Shanghai Chest Hospital, Shanghai, , China
Liaoning Cancer Hospital & Institute, Shenyang, , China
Sichuan Provincial People's Hospital, Sichuan, , China
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, , China
Northern Jiangsu People's Hospital, Yangzhou, , China
Hangzhou Cancer Hospital, Zhejiang, , China
Hwa Mei Hospital, University of Chinese Academy of Sciences, Zhejiang, , China
Centre Hospitalier Universitaire d'Amiens - Hopital Sud, Amiens Cedex 1, Picardie, France
Hôpital de la Timone, Marseille, , France
Hopital Europeen Georges Pompidou - Digestive Oncology, Paris, , France
CHU de Poitiers, Poitiers, , France
Ajou University Hospital, Gyeonggi-do, , Korea, Republic of
Chonnam National University Hwasun Hospital, Jeongnam, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Korea University Guro Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, , Korea, Republic of
Hospital Clínic de Barcelona, Barcelona, , Spain
Hospital de la Santa Creu i Sant Pau, Barcelona, , Spain
Hospital Universitario Vall d'Hebron, Barcelona, , Spain
Institut Catala D'Oncologia, L'Hospitalet De Llobregat, , Spain
Hospital Universitario Madrid Sanchinarro, Madrid, , Spain
Hospital Universitario Ramón y Cajal, Madrid, , Spain
Hospital Regional Universitario de Málaga, Málaga, , Spain
Hospital Universitario Marqués de Valdecilla, Santander, , Spain
Hospital Clinico Universitario de Valencia - Incliva, Valencia, , Spain
Hospital Universitario Miguel Servet, Zaragoza, , Spain
Chiayi Chang Gung Memorial Hospital, Chiayi City, , Taiwan
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, , Taiwan
China Medical University Hospital, Taichung, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Taipei Veterans General Hospital, Taipei, , Taiwan
Linkou Chang Gung Memorial Hospital, Taoyuan, , Taiwan
Chulabhorn Hospital, Bangkok, , Thailand
Phramongkutklao Hospital, Bangkok, , Thailand
Rajavithi Hospital, Bangkok, , Thailand
Siriraj Hospital, Bangkok, , Thailand
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University, Chiang Mai, , Thailand
Songklanagarind Hospital, Prince of Songkla University, Hat Yai, , Thailand
Contact Details
Name: Study Director
Affiliation: BeiGene
Role: STUDY_DIRECTOR
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