Spots Global Cancer Trial Database for Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients

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Trial Identification

Brief Title: Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients

Official Title: Post-operative Radiotherapy Randomization in Poor Responders Ewing's Sarcoma Patients

Study ID: NCT01734863

Conditions

Ewing's Sarcoma

Interventions

External Beam Radiotherapy

Study Description

Brief Summary: Local recurrence after surgical resection is a complex phenomenon. An important predictive factor is the response to chemotherapy. Central site of disease may be a second independent predictive factor (Lin et al. 2007). Patients with more than 10% viable tumour cells at surgery following neo-adjuvant chemotherapy had a less favourable outcome with an Event-free Survival \[EFS\] of 47% after 10 years. Patients with good histological response (\< 10% viable tumour cells) after chemotherapy alone had a prognosis of about 70% after 10 years. However, further studies are necessary to determine the merit of adjuvant radiation for high-risk patients (poor responders). Taking into consideration that the toxicity and morbidity of combined surgery and radiation is greater than either alone and must be closely monitored.

Detailed Description: