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Spots Global Cancer Trial Database for Observational Study on Skeletal Ewing's Sarcoma

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Trial Identification

Brief Title: Observational Study on Skeletal Ewing's Sarcoma

Official Title: Observational Study on Treatment of Skeletal Ewing Sarcoma at Diagnosis

Study ID: NCT04845893

Study Description

Brief Summary: Observational prospective trial aimed to collect the collect demographic, clinical, surgical, pathological and molecular characteristics and treatment from patients affected by skeletal Ewing Sarcoma

Detailed Description: The Ewing sarcoma treatment is based on chemotherapy, surgery and radiotherapy. Chemotherapy, performed with a combination of several drugs, is given as primary treatment before surgery. Surgical intervention must be performed in all cases in which it is possible to obtain an excision with free margins and with acceptable functional deficits. However, when, after surgery in case of incomplete resection, post-operative radiotherapy is used, in order to reduce the risk of local recurrence as much as possible. Subsequently in the local treatment, a phase of maintenance chemotherapy is foreseen, the intensity of which is modulated according to the response to induction therapy. The treatments are carried out with different programs for patients with localized disease or metastatic disease and derive from clinical trials carried out in the last 30 years. These results are the result of national and international prospective trials which, precisely due to the rarity of the disease, took many years to execute, and it is significant to know that randomized studies were in very limited numbers, as almost all the studies were represented by studies of uncontrolled phase II Improving treatments requires the expansion of knowledge on the biological behavior of this tumor and the acquisition of as much information as possible deriving from clinical experience. For this reason, pending the definition of a new prospective randomized trial, which will take time (approximately two years) to be made operational, it is considered useful from a scientific point of view to prospectively collect data relating to new cases of Ewing's sarcoma 'bone.

Eligibility

Minimum Age: 0 Years

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Istituto Clinico Humanitas, Rozzano, MI, Italy

Centro di Riferimento Oncologico - Unit of Medical Oncology, Aviano, Pordenone, Italy

I.R.C.C. - Unit of Medical Oncology, Candiolo, Torino, Italy

Azienda ospedaliero universitaria consorziale policlinico - bari, Bari, , Italy

A.O. Universitaria Policlinico S. Orsola Malpighi di Bologna, Bologna, , Italy

Istituto ortopedico Rizzoli, Bologna, , Italy

A.O. Universitaria Meyer, Firenze, , Italy

Istituto Giannina Gaslini, Genova, , Italy

FONDAZIONE IRCCS Istituto Nazionale dei Tumori, Milano, , Italy

FONDAZIONE IRCCS Istituto Nazionale dei Tumori, Milano, , Italy

Azienda Ospedaliera Santobono Pausilipon, Napoli, , Italy

Azienda Ospedaliera di Padova, Padova, , Italy

ARNAS P. O. "Civico e Benfratelli", Palermo, , Italy

Azienda Ospedaliera Universitaria di Parma, Parma, , Italy

Azienda Ospedaliero-Universitaria Pisana, Pisa, , Italy

Ospedale Pediatrico Bambin Gesu', Roma, , Italy

Istituto Regina Elena - IFO, Rome, , Italy

Ospedale Infantile Regina Margherita - Unit of Paediatric Oncoematology, Torino, , Italy

IRCCS materno infantile Burlo Garofolo, Trieste, , Italy

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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