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Spots Global Cancer Trial Database for Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma

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Trial Identification

Brief Title: Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma

Official Title: Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma

Study ID: NCT06340204

Conditions

Ewing Sarcoma

Study Description

Brief Summary: The investigators explored the safety and activity of weekly irinotecan liposomes in patients with relapsed and metastatic Ewing Sarcoma.

Detailed Description: After standard multimodal therapy, the prognosis of relapsed and metastatic Ewing Sarcoma is dismal and unchanged over the last decades. The anti-tumor activity of irinotecan was demonstrated by several studies in the past. However, longer schedule of irinotecan infusion (traditionally dx5x2) has impacted quality of life in these patients. The irinotecan liposomes may be more active than the parent compound irinotecan since its ability to stay longer in circulation system, and much more convenient to given weekly. Thus, the investigators explored the safety and activity of weekly irinotecan liposomes in patients with relapsed and metastatic Ewing Sarcoma after the failure of first-line chemotherapy with doxorubicin, vincristine, cyclophosphamide, ifosphamide and etoposide. Bayesian Optimal Interval (BOIN) design is adopted in this dose-finding study.

Keywords

Eligibility

Minimum Age: 8 Years

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Shandong Cancer Hospital and Institute, Jina, Shandong, China

Peking University Shougang Hospital, Beijing, , China

Peking University People's Hospital, Beijin, , China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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