Spots Global Cancer Trial Database for Effect of FMD on Colorectal Cancer Patients
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Trial Identification
Brief Title: Effect of FMD on Colorectal Cancer Patients
Official Title: Effect of Perioperative Dietary Restriction Strategy on Postoperative Recovery and Outcomes of Patients With Colorectal Cancer : a Multicenter Prospective, Randomized, Controlled Study
Study ID: NCT05384444
Interventions
Study Description
Brief Summary: Extensive preclinical evidence suggests that short-term fasting and fasting mimicking diets (FMDs) can protect healthy cells and render cancer cells more vulnerable to chemotherapy and other therapies. However, fasting is difficult for the old and frail subjects.Therefore, FMDs may be more suitable for postoperative dietary intervention in cancer patients. Colorectal tumors have high glucose consumption, which makes tumor cells very sensitive to changes in nutritional metabolism of the surrounding environment (such as diet restriction / fasting). Previous studies have shown that cyclic FMDs are safe and feasible for cancer patients receiving chemotherapy alone. However, the effects of the FMD in patients under radical surgery for colorectal cancer have not been evaluated so far. This study aims to evaluate the impact of FMDs on postoperative recovery and outcomes of patients with colorectal cancer.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fudan University Huashan Hospital, Shanghai, Shanghai, China
Fudan University Shanghai Cancer center, Shanghai, Shanghai, China
Fudan University,ZhongShan Hospital, Shanghai, Shanghai, China
Shanghai Changhai Hospital, Naval Medical University,, Shanghai, Shanghai, China
Shanghai First People's Hospital,Shanghai Jiaotong University, Shanghai, Shanghai, China
Shanghai Tongji Hospital,Tongji University, Shanghai, Shanghai, China
Contact Details
Name: Miaomiao Guo, Dr
Affiliation: Shanghai Zhongshan Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Meilin Weng, PhD
Affiliation: Shanghai Zhongshan Hospital
Role: PRINCIPAL_INVESTIGATOR
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