Spots Global Cancer Trial Database for Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents
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Trial Identification
Brief Title: Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents
Official Title: Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents
Study ID: NCT02335437
Interventions
Study Description
Brief Summary: Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents undergoing acute EBV infection will be followed prospectively, and also compared with a group of healthy controls. The aim is twofold: * To identify factors that predispose to chronic fatigue among adolescents with acute EBV infection * To compare pathophysiological features of patients with acute EBV infection with a group of healthy controls. Possible risk factors for chronic fatigue 6 months after EBV-infection includes: * Severity of the initial infection * Immune responses characteristics * Characteristics of the neuroendocrine stress response * Cognitive functioning * Emotional disturbances * Genetics/ epigenetics of candidate genes * Certain personality traits * Critical life events
Detailed Description:
Keywords
Eligibility
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Dept. of Pediatrics, Akershus University Hospital, Lørenskog, Akershus, Norway
Contact Details
Name: Vegard B Wyller
Affiliation: University Hospital, Akershus
Role: PRINCIPAL_INVESTIGATOR
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