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Brief Title: Anesthesia and Circulating Tumor Cells in Breast Cancer
Official Title: Does Anesthesia Technique Affect the Presence of Circulating Tumor Cells in Primary Breast Carcinoma? A Randomised Controlled Trial.
Study ID: NCT02005770
Brief Summary: Serious concern about the role of anesthesia in tumor recurrence has considerably risen over years, but the lack of surrogate markers for tumor spreading made trials addressing this issue difficult to realize. In breast cancer patients CTC positivity has been recently recognized as an independent prognostic factor. In this respect, we postulated that in a first step changes in the number of CTC after general anesthesia would help to determine the effect of anesthesia on this tumor marker.
Detailed Description: Patients with primary breast cancer will be randomized to either propofol or sevoflurane anesthesia for curative surgery. CTC will be determined in the pre- as well as postoperative phase and the kinetic of CTC in the two groups will be compared.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
University Hospital Zurich, Institute of Anesthesiology, Zurich, ZH, Switzerland
Institute of Physicians for Anesthesia and Intensive Care Klinik Hirslanden, Zurich, , Switzerland
Name: Beatrice Beck Schimmer, Prof MD
Affiliation: University Hospital Zurich, Institute of Anesthesiology
Role: PRINCIPAL_INVESTIGATOR