Spots Global Cancer Trial Database for Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)
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Trial Identification
Brief Title: Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)
Official Title: Role of Senescent Cells in Uterine Fibroid Pathogenesis
Study ID: NCT06135870
Interventions
Study Description
Brief Summary: The investigators are evaluating the role of senescent cells in uterine fibroids.
Detailed Description: Uterine fibroids are prevalent tumors of uterus characterized by excessive fibrotic tissues. Using new cutting-edge computational methods, the investigators have found that small groups of senescent cells in fibroids work in concert with immune cells to produce soluble factors in fibroid tissues to create a feed-forward loop leading to fibrosis. This project seeks to unravel key cell-cell communication networks involving senescent and immune cells in fibroids to develop new treatments for uterine fibroids.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Johns Hopkins Hospital, Baltimore, Maryland, United States
Contact Details
Name: James Segars, MD
Affiliation: Johns Hopkins University
Role: PRINCIPAL_INVESTIGATOR
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