Spots Global Cancer Trial Database for A Study of Pinatuzumab Vedotin (DCDT2980S) Combined With Rituximab or Polatuzumab Vedotin (DCDS4501A) Combined With Rituximab or Obinutuzumab in Participants With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)
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Trial Identification
Brief Title: A Study of Pinatuzumab Vedotin (DCDT2980S) Combined With Rituximab or Polatuzumab Vedotin (DCDS4501A) Combined With Rituximab or Obinutuzumab in Participants With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)
Official Title: A Randomized, Open-Label, Multicenter, Phase II Trial Evaluating the Safety and Activity of Pinatuzumab Vedotin (DCDT2980S) in Combination With Rituximab or Polatuzumab Vedotin (DCDS4501A) in Combination With Rituximab and a Non-Randomized Phase Ib/II Evaluation of Polatuzumab Vedotin in Combination With Obinutuzumab in Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma
Study ID: NCT01691898
Study Description
Brief Summary: This multicenter, open-label study will evaluate the safety and efficacy of pinatuzumab vedotin (DCDT2980S) or polatuzumab vedotin (DCDS4501A) in combination with rituximab (RTX), as well as of polatuzumab vedotin in combination with obinutuzumab in participants with relapsed or refractory (r/r) follicular lymphoma (FL) and r/r diffuse large B-cell lymphoma (DLBCL).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Cedars-Sinai Medical Center, Los Angeles, California, United States
Stanford Cancer Center, Stanford, California, United States
Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center, Denver, Colorado, United States
Georgetown University Medical Center Lombardi Cancer Center, Washington, District of Columbia, United States
Florida Cancer Specialists - Fort Myers (Colonial Center Dr), Fort Myers, Florida, United States
Florida Cancer Specialists; Sarasota, Sarasota, Florida, United States
Univ of Michigan Med School; Hematology Oncology, Ann Arbor, Michigan, United States
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas, Nevada, United States
Hematology Oncology Associates; Carol G. Simon Ctr, Morristown, New Jersey, United States
Regional Cancer Care Associates LLC - Morristown, Morristown, New Jersey, United States
Roswell Park Cancer Inst., Buffalo, New York, United States
New York University Cancer Cen, New York, New York, United States
Oncology Hematology Care Inc, Cincinnati, Ohio, United States
Willamette Valley Cancer Ctr - 520 Country Club, Eugene, Oregon, United States
Oregon Health Sciences Uni, Portland, Oregon, United States
Sarah Cannon Cancer Center - Tennessee Oncology, Pllc, Nashville, Tennessee, United States
Texas Oncology-Baylor Sammons Cancer Center, Dallas, Texas, United States
Cancer Care Centers of South Texas, San Antonio, Texas, United States
Texas Transplant Inst., San Antonio, Texas, United States
Texas Oncology, P.A. - Tyler; Tyler Cancer Center, Tyler, Texas, United States
Fairfax N Virginia Hem/Onc PC, Fairfax, Virginia, United States
Oncology & Hematolgy Associates of SW Va Inc. - Roanoke, Roanoke, Virginia, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Northwest Cancer Specialists - Vancouver, Vancouver, Washington, United States
Yakima Valley Memorial Hospital/North Star Lodge, Yakima, Washington, United States
Univ of Wisconsin-Madison, Madison, Wisconsin, United States
Cross Cancer Institute, Edmonton, Alberta, Canada
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal, Quebec, Canada
Hopital Claude Huriez - CHU Lille, Lille, , France
CHU Montpellier - Saint ELOI, Montpellier, , France
Hopital Saint Louis ; Service d Oncologie Medicale Fougere 6 (Pr Misset), Paris, , France
Centre Hospitalier Lyon Sud, Pierre Benite, , France
Centre Henri Becquerel; Hematologie, Rouen, , France
Uniklinik Heidelberg, Medizinische Klinik & Poliklinik V, Heidelberg, , Germany
Universitätsmedizin Johannes Gutenberg Universität; Klinik u. Poliklinik f. Neurologie, Mainz, , Germany
Klinikum d.Universität München Campus Großhadern, München, , Germany
A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna, Bologna, Emilia-Romagna, Italy
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milano, Lombardia, Italy
Azienda Ospedale San Giovanni, Torino, Piemonte, Italy
Academisch Medisch Centrum; Hematologie, Amsterdam, , Netherlands
Contact Details
Name: Clinical Trials
Affiliation: Genentech, Inc.
Role: STUDY_DIRECTOR
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