Spots Global Cancer Trial Database for Safety and Efficacy of Fludarabine and Cyclophosphamide + Rituximab

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Trial Identification

Brief Title: Safety and Efficacy of Fludarabine and Cyclophosphamide + Rituximab

Official Title: Phase II Study of Rituximab in Combination With Fludarabine and Cyclophosphamide for the Treatment of Relapsed Follicular Lymphoma

Study ID: NCT00393107

Conditions

Follicular Lymphoma

Interventions

rituximab

rituximab,fludarabine, cyclophosphamide

Study Description

Brief Summary: Purpose of this study was to assess the safety profile and the anti-lymphoma activity of the FC+R combination.

Detailed Description: The natural history of follicular lymphomas is characterized by a high initial response rate to chemotherapy followed invariably by relapse, with subsequent remissions of progressively shorter duration. The majority of patients eventually die of their disease. As yet, there is no gold standard for the treatment of newly diagnosed or relapsed advanced FL.Rituximab(R) has been shown to be a highly effective agent in the treatment of FL, either alone or in combination with chemotherapy. The ability of R to sensitize indolent lymphoma derived cell lines to cytotoxic chemotherapy agents has been demonstrated. Furthermore, fludarabine (F) may also sensitize cells to the effects of R. Cyclophosphamide (C) and F have shown in vivo synergistic activity. In view of the single agent activity and demonstrated synergy between C and F, and between F and R, we evaluated FC+R in previously treated patients with advanced FL. The primary aim of this study was to assess the safety profile and clinical activity of the FC+R combination. The secondary goal was to evaluate the ability of the treatment to convert bone marrow Bcl2 positivity such that patients achieved molecular remissions.