Spots Global Cancer Trial Database for Evaluation of Atezolizumab-Venetoclax-Obinutuzumab Combination in Relapse/Refractory Lymphomas
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Trial Identification
Brief Title: Evaluation of Atezolizumab-Venetoclax-Obinutuzumab Combination in Relapse/Refractory Lymphomas
Official Title: A Phase II Trial Evaluating Combination of Atezolizumab, With Venetoclax and Obinutuzumab for Relapsed/Refractory Lymphomas
Study ID: NCT03276468
Study Description
Brief Summary: This study is a multicenter phase II trial which primary objective is to assess the anti-lymphoma activity of atezolizumab associated with a BCL-2 inhibitor (GDC-199, venetoclax) and an anti-CD20 monoclonal antibody (obinutuzumab) in three separate cohorts: * relapsed/refractory follicular lymphoma (FL) patients * relapsed/refractory aggressive (DLBCL) lymphoma patients * relapsed/refractory other indolent (iNHL) lymphoma patients (MZL and MALT)
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
CHU d'Angers, Angers, , France
CHU de Caen, Caen, , France
CHU de Clermont Ferrand - Estaing, Clermont-Ferrand, , France
Hopital Henri Mondor, Créteil, , France
CHU de Dijon, Dijon, , France
CH Annecy Gennevois, Epagny, , France
CHD de Vendée, La Roche-sur-Yon, , France
CHU de Grenoble, La Tronche, , France
CHRU de Lille, Lille, , France
Centre Léon Bérard, Lyon, , France
Institut Paoli Calmettes, Marseille, , France
CHU de Montpellier, Montpellier, , France
CHU de Nancy - Brabois, Nancy, , France
CHU de Nantes, Nantes, , France
CHU de Nice, Nice, , France
Hôpital Saint Louis, Paris, , France
Hôpital Necker, Paris, , France
CHU Lyon Sud, Pierre Bénite, , France
CHU de Poitiers, Poitiers, , France
CHU de Rennes - Hôpital de Pontchaillou, Rennes, , France
Centre Henri Becquerel, Rouen, , France
Institut Curie - Hôpital René Huguenin, Saint-Cloud, , France
CHRU de Strasbourg, Strasbourg, , France
Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, , France
CHRU de Tours, Tours, , France
Contact Details
Name: Guillaume CARTRON, PhD
Affiliation: Lymphoma Study Association
Role: PRINCIPAL_INVESTIGATOR
Name: Charles HERBAUX, MD
Affiliation: Lymphoma Study Association
Role: PRINCIPAL_INVESTIGATOR
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