Spots Global Cancer Trial Database for Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
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Trial Identification
Brief Title: Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
Official Title: Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
Study ID: NCT05652348
Study Description
Brief Summary: Patients with gastric or colon cancer with peritoneal carcinomatosis will receive a biopsy of the tumor during their primary curative surgery. The operation is performed according to standard and includes resection of the primary tumor and any metastases and followed by HIPEC (Intraperitoneal hyperthermic chemoperfusion) according to the respective hospital standard. Organoid cultures from the biopsies are established in the research laboratory. Various chemotherapeutic agents are tested on these tumor organoids in the laboratory and the tumor organoids are analyzed in detail with regard to genetic alterations in order to find alterations that can be addressed, if necessary, by means of targeted drugs against peritoneal carcinomatosis.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustv Carus Dresden, Dresden, , Germany
University Hospital Heidelberg, Heidelberg, , Germany
Contact Details
Name: Daniel Stange, Prof. Dr.
Affiliation: University Hospital Carl Gustav Carus Dresden
Role: PRINCIPAL_INVESTIGATOR
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