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Brief Title: First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma
Official Title: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study of Rilotumumab (AMG102) With Epirubicin, Cisplatin, and Capecitabine (ECX) as First-line Therapy in Advanced MET-Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Study ID: NCT01697072
Brief Summary: This is a phase 3, multicenter, randomized, double-blind, placebo controlled study of epirubicin, cisplatin \& capecitabine (ECX) with rilotumumab or placebo for untreated advanced MET-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Research Site, Tucson, Arizona, United States
Research Site, Aurora, Colorado, United States
Research Site, Pueblo, Colorado, United States
Research Site, Chicago, Illinois, United States
Research Site, Baltimore, Maryland, United States
Research Site, Woodbury, Minnesota, United States
Research Site, Henderson, Nevada, United States
Research Site, New York, New York, United States
Research Site, Rochester, New York, United States
Research Site, Greensboro, North Carolina, United States
Research Site, Winston Salem, North Carolina, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Nashville, Tennessee, United States
Research Site, Bedford, Texas, United States
Research Site, Dallas, Texas, United States
Research Site, Seattle, Washington, United States
Research Site, Randwick, New South Wales, Australia
Research Site, St Leonards, New South Wales, Australia
Research Site, Tweed Heads, New South Wales, Australia
Research Site, Douglas, Queensland, Australia
Research Site, Elizabeth Vale, South Australia, Australia
Research Site, Kurralta Park, South Australia, Australia
Research Site, Heidelberg, Victoria, Australia
Research Site, Ringwood East, Victoria, Australia
Research Site, Graz, , Austria
Research Site, Innsbruck, , Austria
Research Site, Linz, , Austria
Research Site, Salzburg, , Austria
Research Site, Wien, , Austria
Research Site, Bruxelles, , Belgium
Research Site, Bruxelles, , Belgium
Research Site, Charleroi, , Belgium
Research Site, Edegem, , Belgium
Research Site, Liege, , Belgium
Research Site, Roeselare, , Belgium
Research Site, Belo Horizonte, Minas Gerais, Brazil
Research Site, Pelotas, Rio Grande do Sul, Brazil
Research Site, Santo Andre, São Paulo, Brazil
Research Site, Sao Paulo, São Paulo, Brazil
Research Site, Sao Paulo, São Paulo, Brazil
Research Site, São Paulo, , Brazil
Research Site, Plovdiv, , Bulgaria
Research Site, Shumen, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Varna, , Bulgaria
Research Site, Vancouver, British Columbia, Canada
Research Site, London, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Greenfield Park, Quebec, Canada
Research Site, Laval, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Horovice, , Czech Republic
Research Site, Hradec Kralove, , Czech Republic
Research Site, Olomouc, , Czech Republic
Research Site, Praha 2, , Czech Republic
Research Site, Usti nad Labem, , Czech Republic
Research Site, Aalborg, , Denmark
Research Site, Copenhagen, , Denmark
Research Site, Odense, , Denmark
Research Site, Århus C, , Denmark
Research Site, Bayonne, , France
Research Site, Bordeaux, , France
Research Site, Clermont Ferrand Cedex 1, , France
Research Site, Dijon cedex, , France
Research Site, Le Mans, , France
Research Site, Limoges Cedex, , France
Research Site, Lyon Cedex 03, , France
Research Site, Lyon Cedex 08, , France
Research Site, Marseille cedex 5, , France
Research Site, Montpellier Cedex 5, , France
Research Site, Nice cedex 2, , France
Research Site, Périgueux cedex, , France
Research Site, Saint Priest en Jarez Cedex, , France
Research Site, Saint Priest en Jarez, , France
Research Site, Strasbourg, , France
Research Site, Berlin, , Germany
Research Site, Bielefeld, , Germany
Research Site, Dresden, , Germany
Research Site, Essen, , Germany
Research Site, Frankfurt am Main, , Germany
Research Site, Leipzig, , Germany
Research Site, Magdeburg, , Germany
Research Site, Mainz, , Germany
Research Site, München, , Germany
Research Site, München, , Germany
Research Site, Oldenburg, , Germany
Research Site, Schweinfurt, , Germany
Research Site, Athens, , Greece
Research Site, Heraklion - Crete, , Greece
Research Site, Larissa, , Greece
Research Site, Nea Kifissia, Athens, , Greece
Research Site, Patra, , Greece
Research Site, Thessaloniki, , Greece
Research Site, Thessaloniki, , Greece
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Gyor, , Hungary
Research Site, Nyiregyhaza, , Hungary
Research Site, Szeged, , Hungary
Research Site, Szolnok, , Hungary
Research Site, Aviano PN, , Italy
Research Site, Brescia, , Italy
Research Site, Catania, , Italy
Research Site, Firenze, , Italy
Research Site, Napoli, , Italy
Research Site, Pisa, , Italy
Research Site, Roma, , Italy
Research Site, Mexico, Distrito Federal, Mexico
Research Site, Cuernavaca, Morelos, Mexico
Research Site, Distrito Federal, , Mexico
Research Site, Toluca, , Mexico
Research Site, Bialystok, , Poland
Research Site, Elblag, , Poland
Research Site, Gdansk, , Poland
Research Site, Konin, , Poland
Research Site, Lodz, , Poland
Research Site, Warszawa, , Poland
Research Site, Aveiro, , Portugal
Research Site, Guimaraes, , Portugal
Research Site, Lisboa, , Portugal
Research Site, Porto, , Portugal
Research Site, Santa Maria da Feira, , Portugal
Research Site, Vila Real, , Portugal
Research Site, Alba Iulia, , Romania
Research Site, Baia Mare, , Romania
Research Site, Brasov, , Romania
Research Site, Bucharest, , Romania
Research Site, Bucharest, , Romania
Research Site, Bucharest, , Romania
Research Site, Cluj Napoca, , Romania
Research Site, Cluj-Napoca, , Romania
Research Site, Cluj-Napoca, , Romania
Research Site, Lasi, , Romania
Research Site, Timisoara, , Romania
Research Site, Chelyabinsk, , Russian Federation
Research Site, Ivanovo, , Russian Federation
Research Site, Kazan, , Russian Federation
Research Site, Krasnodar, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Saint-Petersburg, , Russian Federation
Research Site, Samara, , Russian Federation
Research Site, Vladimir, , Russian Federation
Research Site, Bardejov, , Slovakia
Research Site, Bratislava, , Slovakia
Research Site, Poprad, , Slovakia
Research Site, Trencin, , Slovakia
Research Site, Groenkloof, Gauteng, South Africa
Research Site, Cape Town, , South Africa
Research Site, Johannesburg, , South Africa
Research Site, Kraaifontein, , South Africa
Research Site, Pretoria, , South Africa
Research Site, Oviedo, Asturias, Spain
Research Site, Barcelona, Cataluña, Spain
Research Site, L'Hospitalet de Llobregat, Cataluña, Spain
Research Site, Terrassa, Cataluña, Spain
Research Site, A Coruña, Galicia, Spain
Research Site, Pamplona, Navarra, Spain
Research Site, Madrid, , Spain
Research Site, Eskilstuna, , Sweden
Research Site, Stockholm, , Sweden
Research Site, Bellinzona, , Switzerland
Research Site, Bern, , Switzerland
Research Site, Chur, , Switzerland
Research Site, Ankara, , Turkey
Research Site, Gaziantep, , Turkey
Research Site, Istanbul, , Turkey
Research Site, Izmir, , Turkey
Research Site, Dnipropetrovsk, , Ukraine
Research Site, Kharkiv, , Ukraine
Research Site, Kherson, , Ukraine
Research Site, Kyiv, , Ukraine
Research Site, Lutsk, , Ukraine
Research Site, Lviv, , Ukraine
Research Site, Mariupol, , Ukraine
Research Site, Sumy, , Ukraine
Research Site, Uzhgorod, , Ukraine
Research Site, Belfast, , United Kingdom
Research Site, Edinburgh, , United Kingdom
Research Site, Guildford, , United Kingdom
Research Site, Leicester, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Newcastle Upon Tyne, , United Kingdom
Research Site, Northwood, , United Kingdom
Research Site, Salisbury, , United Kingdom
Research Site, Sutton, , United Kingdom
Name: MD
Affiliation: Amgen
Role: STUDY_DIRECTOR