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Spots Global Cancer Trial Database for Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With Diabetes Mellitus

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Trial Identification

Brief Title: Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With Diabetes Mellitus

Official Title: The Effect and Mechanism of Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With DM Who Receive Surgical Treatment

Study ID: NCT01375738

Study Description

Brief Summary: This study is to investigate the effect of gastrectomy on remission of type 2 diabetes in patients with gastric cancer and type 2 diabetes, to investigate the mechanism of blood glucose alteration and intestinal hormonal signaling by the reconstruction methods, and to evaluate the applicability and efficacy of Roux-en-Y gastrojejunostomy after gastrectomy in gastric cancer patients with diabetes.

Detailed Description: Purpose: * To investigate the effect of gastrectomy on remission of type 2 diabetes in patients with gastric cancer and type 2 diabetes * To investigate the mechanism of blood glucose alteration and intestinal hormonal signaling by the reconstruction methods * To evaluate the applicability and efficacy of Roux-en-Y gastrojejunostomy after gastrectomy in gastric cancer patients with diabetes Contents: * Evaluation of the status of diabetes in gastric cancer patients with DM after gastrectomy * Comparison of two reconstruction types after gastrectomy Bypass duodenum and upper jejunum: Roux-en-Y gastrojejunostomy Preservation of duodenal passage: Gastroduodenostomy * Analysis for biochemical markers reflecting diabetic status: fasting glucose, postprandial 2h glucose, HbA1c, C-peptide, lipid profile * Correlation of parameters associated with diabetes and GI hormones * Measurement of GI hormones which have an effect on glucose tolerance * Insulin, glucagon, IGF-1, GLP-1, Neuropeptide Y, Ghrelin, Leptin * Correlation of reconstruction methods, parameters of diabetes and GI hormone levels * Evaluation of mechanism of Roux-en-Y gastrojejunostomy on controlling diabetes * Evaluation of Feasibility of Roux-en-Y gastrojejunostomy in gastric cancer surgery in patients with DM * Degree of high blood glucose control, the amount of antidiabetic medication, costs for DM treatment, quality of life assessment * Analysis for the mechanism of gastrointestinal physiology to diabetes control

Eligibility

Minimum Age: 20 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Severance Hospital, Seoul, , Korea, Republic of

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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