Spots Global Cancer Trial Database for Minnelide™ Capsules Alone and in Combination With Paclitaxel in Advanced Gastric Cancer
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Trial Identification
Brief Title: Minnelide™ Capsules Alone and in Combination With Paclitaxel in Advanced Gastric Cancer
Official Title: A Phase 1 Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Paclitaxel in Patients With Advanced Gastric Cancer
Study ID: NCT05566834
Conditions
Interventions
Study Description
Brief Summary: A Phase 1, Open-label, Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of Minnelide™ Capsules given alone or in combination with paclitaxel in patients with Advanced Gastric Cancer.
Detailed Description: Minnelide™ is a water soluble disodium salt variant of triptolide, a diterpenoid, an HSP70 inhibitor. Studies using orthotopic pancreatic cancer cell lines and human xenograft transplants demonstrate that Minnelide™ prevents tumor progression, increases survival, and causes tumor regression.
Keywords
Eligibility
Minimum Age: 19 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Samsung Medical Center, Soeul, , Korea, Republic of
Contact Details
Name: Mohana Velagapudi
Affiliation: Minneamrita Therapeutics LLC
Role: STUDY_DIRECTOR
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