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Spots Global Cancer Trial Database for Trial of Panitumumab Cisplatin, Fluourouracil and Docetaxel in Locally Advanced or Metastatic Gastric Cancer

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Trial Identification

Brief Title: Trial of Panitumumab Cisplatin, Fluourouracil and Docetaxel in Locally Advanced or Metastatic Gastric Cancer

Official Title: Phase I/II, Multicenter, Single-Arm Clinical Trial of Panitumumab in Combination With Cisplatin, Fluourouracil and Docetaxel (DCF) in Locally Advanced or Metastatic Cancer of the Stomach and Gastro-oesophageal Junction.

Study ID: NCT01716546

Conditions

Gastric Cancer

Interventions

Pazopanib

Study Description

Brief Summary: Investigators propose to study the effect of panitumumab when combined with an active regimen, such as DCF (Docetaxel/Cisplatin/Fluourouracil), in previously untreated patients with advanced cancer of the stomach.

Detailed Description: Investigators propose a phase I/II study in order to evaluate the effect of panitumumab when combined with an active regimen, such as DCF (Docetaxel/Cisplatin/Fluourouracil), in chemotherapy - naive patients with advanced cancer of the stomach. Investigators hypothesize that the addition of panitumumab to DCF regimen in advanced cancer of the stomach and gastroesophageal junction is feasible, well tolerated and could achieve an objective response rate of greater than 40%. The 2-weekly schedule of DCF will be used as chemotherapy since a recently presented trial demonstrated a comparable efficacy but a more favourable toxicity profile comparable to the 3-weekly schedule.

Eligibility

Minimum Age: 20 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

"IASO" General Hospital of Athens, Athens, , Greece

401 Military Hospital of Athens, Athens, , Greece

Air Forces Military Hospital of Athens, Athens, , Greece

"Ag.Georgios" General Hospital of Chania, Chania, , Greece

University Hospital of Crete, Dep of Medical Oncology Heraklion, Greece, Heraklion, , Greece

State General Hospital of Larissa, Larissa, , Greece

"Metaxa's" Anticancer Hospital of Piraeus, 1st Dep of Medical Oncology, Piraeus, , Greece

"Theagenion" Anticancer Hospital of Thessaloniki, 2nd Dep of Medical Oncology, Thessaloniki, , Greece

Diabalkaniko General Hospital of Thessaloniki, Thessaloniki, , Greece

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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