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Brief Title: A Study to Evaluate Rivoceranib Plus Best Supportive Care Compared to Placebo Plus Best Supportive Care in Participants With Gastric Cancer
Official Title: A Prospective, Randomized, Double-Blinded, Placebo-Controlled, Multinational, Multicenter, Parallel-group, Phase III Study to Evaluate the Efficacy and Safety of Apatinib Plus Best Supportive Care (BSC) Compared to Placebo Plus BSC in Patients With Advanced or Metastatic Gastric Cancer
Study ID: NCT03042611
Brief Summary: The purpose of this study is to evaluate the efficacy and safety of rivoceranib plus best supportive care (BSC) compared to placebo plus BSC in participants with advanced or metastatic gastric cancer (GC).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic Phoenix, Scottsdale, Arizona, United States
Highlands Oncology Group, Rogers, Arkansas, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
Hudson Valley Cancer Centre, Hawthorne, New York, United States
Centre Hospitalier Franco-Britannique; Oncologie Médicale, Levallois-Perret, , France
Centre Leon-Berard (CLB), Lyon, , France
Institut Regional du Cancer Montpellier (ICM), Montpellier, , France
Centre Antoine-Lacassagne, Nice, , France
Institut Gustave Roussy, Villejuif, , France
Charite - Universitaetsmedizin Berlin - Medizinische Klinik mit Schwerpunkt Haematologie, Onkologie und Tumorimmunologie, Berlin, , Germany
"Institut für Klinisch-Onkologische Forschung (IKF) Krankenhaus Nordwest gGmbH UCT - Universitäres Centrum für Tumorerkrankungen Frankfurt, Frankfurt, , Germany
Facharztzentrum Eppendorf - Haematologisch-Onkologische Praxis Eppendorf (HOPE), Hamburg, , Germany
Universitätsklinik Marburg, Klinik fur Innere Medizin, Schwerpunkt Haematologie, Onkologie und Immunologie, Marburg, , Germany
Magna Graecia University- Department of Experimental and Clinical Medicine, Catanzaro, , Italy
U.O Di Oncologia Ospedale Degli Infermi, Faenza, , Italy
Fondazione IRCCS-Istituto Nazionale Tumori, Milano, , Italy
Policlinico di Modena-Azienda Ospedaliero Universitaria di Modena.Oncologia ed Ematologia., Modena, , Italy
Veneto Oncology Institute (IOV-IRCCS), Melanoma & Esophageal Oncology Unit, Padova, , Italy
Ospedale di Piacenza - Oncology and heamatology, Piacenza, , Italy
Ospedale "Felice Lotti", Pontedera, , Italy
IRCCS/Arcispedale Santa Maria Nuova, Reggio Emilia, , Italy
Rimini Hospital, Rimini, , Italy
Ospedali Riuniti di Ancona - SOD Clinica Oncologica, Torrette, , Italy
Hyogo Cancer Center, Hyogo, Akasi-city, Japan
Chiba Cancer Center, Chiba, Chiba City, Japan
National Cancer Center Hospital, Tokyo, Chuo-ku, Japan
Kyushu University Hospital, Fukuoka, Higashi-ku, Japan
National Cancer Center Hospital East, Chiba, Kashiwa, Japan
St. Marianna University School of Medicine Hospital, Kanagawa, Kawasaki-shi, Japan
Saitama Cancer Center, Saitama, Kitaadachi-gun, Japan
Japan Community Health Care Organization Kyushu Hospital, Fukuoka, Kitakyushu-shi, Japan
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo, Koto-ku, Japan
National Hospital Organization Shikoku Cancer Center, Ehime, Matsuyama, Japan
Saku Central Hospital Advanced Care Center, Nagano, Saku-shi, Japan
Hokkaido University Hospital, Hokkaido, Sapporo, Japan
Keio University Hospital, Tokyo, Shinjuku-ku, Japan
Osaka University Hospital, Osaka, Suita, Japan
Aichi Cancer Center Hospital, Nagoya, , Japan
Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Korea, Republic of
National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of
Ajou University Hospital, Suwon-si, Gyonggi-do, Korea, Republic of
Inje University Haeundae Paik Hospital, Busan, , Korea, Republic of
Dong-A University Hospital, Busan, , Korea, Republic of
Pusan National University Hospital, Busan, , Korea, Republic of
Chungbuk National University Medical Center, Chuncheon, , Korea, Republic of
Chungbuk National University Hospital, Chungbuk, , Korea, Republic of
Kyungpook National University Medical Center, Daegu, , Korea, Republic of
Keimyung University Dongsan Medical Center, Daegu, , Korea, Republic of
Yeungnam University Medical Center, Daegu, , Korea, Republic of
Chungnam National University Hospital, Daejeon, , Korea, Republic of
Seoul National University Bundang Hospital, Gyeonggi-do, , Korea, Republic of
Gachon University Gil Medical Center, Incheon, , Korea, Republic of
Korea University Anam Hospital, Seoul, , Korea, Republic of
Severence Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Veterans Health Service (VHS) Medical Center, Seoul, , Korea, Republic of
ASAN Medical Center, Seoul, , Korea, Republic of
Gangnam Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Korea University Guro Hospital, Seoul, , Korea, Republic of
Ulsan University Hospital, Ulsan, , Korea, Republic of
Szpital Uniwersytecki w Krakowie, Odział Kliniczny Onkologii, Kraków, , Poland
Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie, Klinika Gastroenterologii Onkologicznej, Warszawa, , Poland
Saint Constantin Hospital (TEO HEALTH SA), Brasov, , Romania
Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj-Napoca, Sectia de Radioterapie I, Cluj-Napoca, , Romania
S.C. Medisprof S.R.L., Cluj-Napoca, , Romania
Centrul de Oncologie "Sf. Nectarie", Sectia de Oncologie Medicala, Craiova, , Romania
State Budgetary Healthcare Institution of Arkhangelsk Region "Arkhangelsk Clinical Oncology Dispensary", Arkhangelsk, , Russian Federation
State Healthcare Institution "Kursk Regional Clinical Oncology Dispensary", Kursk, , Russian Federation
Omsk regional clinical oncology center, Omsk, , Russian Federation
Budgetary Healthcare Institution of Orel Region "Orel Oncology Dispensary", Oryol, , Russian Federation
State Budgetary Healthcare Institution of Stavropol Territory "Pyatigorsk Oncology Dispensary", Pyatigorsk, , Russian Federation
Ogarev Mordovia State University, Saransk, , Russian Federation
Federal State Budgetary Educational Institution of Higher Education "Academician I.P. Pavlov First St. Petersburg State Medical University" of the Ministry of Heaithcare of the Russian Federation, St. Petersburg, , Russian Federation
State Budgetary Healthcare Institution "Republican Clinical Oncology Dispensary", Ufa, , Russian Federation
Taipei Veterans General Hospital, Taipei, Beitou Dist, Taiwan
Chang Gung Memorial Hospital - Linko Branch, Taoyuan, Kuei Shan Hsiang, Taiwan
Chi Mei Medical Center - LiouYing Branch, Tainan, Liuying DIst, Taiwan
Chang Gung Memorial Hospital - Kaohsiung Branch, Kaohsiung, Niaosong Dist, Taiwan
Kaohsiung Medical University Hospital, Kaohsiung, Sanmin Dist, Taiwan
China Medical University Hospital, Taichung, Taichung City, Taiwan
National CHeng Kung University Hospital, Tainan, Tainan City, Taiwan
National Taiwan University Hospital, Taipei, Zhongzheng Dist, Taiwan
Dnipropetrovsk Medical Academy, Department of Oncology, Dnipro, , Ukraine
Communal Institution "Ivano-Frankivsk Regional Oncological Center", Ivano-Frankivsk, , Ukraine
Communal Institution "Kharkiv Regional Clinical Oncology Center ", Chemotherapy department #1, Medical Academy of Postgraduate Education, Oncology and Pediatric Oncology, Kharkiv, , Ukraine
Kherson Regional Oncological Dispensary, Kherson, , Ukraine
Municipal Institution Kryvyi Rig Oncology Dispensary", Chemotherapy Department, Kryvyi Rih, , Ukraine
Municipal Institution "Kyiv City Clinical Oncological Center", Kyiv, , Ukraine
Communal Institution "Transcarpathian Regional Clinical Oncological Center", Uzhhorod, , Ukraine
Communal Institution "Vinnytsia Regional Clinical Oncology Dispensary", Vinnytsia, , Ukraine
State institution "Zaporizhzhia Medical Academy of Postgraduate Education MOH Ukraine", Department of oncology based on Municipal Institution "Zaporizhzhia Regional Clinical Oncology Dispensary" Zaporizhzhia Regional Assembly, Zaporizhzhia, , Ukraine
Royal Marsden Hospital London, London, , United Kingdom
The Christie NHS Foundation Trust, Manchester, , United Kingdom
Royal Marsden Hospital Surrey, Sutton, , United Kingdom