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Brief Title: A Study of 5-FU Versus MTX+5-FU in Gastric Cancer With Peritoneal Metastasis
Official Title: Randomized Phase III Study of 5-FU Continuous Infusion (5FUci) Versus MTX+5-FU Sequential Therapy (MF) in Gastric Cancer With Peritoneal Metastasis (JCOG0106-MF, MF/5FU)
Study ID: NCT00149201
Brief Summary: To develop effective chemotherapy regimen against gastric cancer with peritoneal metastasis
Detailed Description: Peritoneal metastasis is common in advanced gastric cancer and is considered an incurable disease state. Peritoneal metastasis may cause serious complications, such as intestinal obstruction, massive ascites, and hydronephrosis associated with the clinical presentation of abdominal pain and fullness, vomiting, constipation, malnutrition and renal dysfunction.5-FU continuous infusion remains the mainstay for chemotherapy against gastric cancer. On the other, sequential MTX+5-FU was reported to be effective in advanced gastric cancer with peritoneal metastasis in some phase II studies. Therefore, the randomized phase III study of 5-FU versus sequential MTX+5-FU in gastric cancer with peritoneal metastasis was conducted.
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Aichi Cancer Center Hospital, 1-1,Kanokoden,Chikusa-ku,Nagoya, Aichi, Japan
Aichi Cancer Center,Aichi Hospital, 18,Kuriyado,Kake-machi,Okazaki, Aichi, Japan
Nagoya Medical Center, 4-1-1,Sannomaru,Naka-ku,Nagoya, Aichi, Japan
Aomori Prefectural Central Hospital, 2-1-1,Higashitsukurimiti,Aomori, Aomori, Japan
National Cancer Center Hospital East, 6-5-1,Kashiwanoha,Kashiwa, Chiba, Japan
Chiba Cancer Center Hospital, 666-2,Nitona-cho,Chuo-ku,Chiba, Chiba, Japan
Asahi General Hospital, I-1326,Asahi, Chiba, Japan
National Hospital Organization Shikoku Cancer Center, 13,Horinouchi,Matsuyama, Ehime, Japan
Kyushu University Hospital, 3-1-1,Maidashi,Higashi-ku, Fukuoka, Japan
National Kyushu Cancer Center, 3-1-1,Notame,Minami-ku,Fukuoka, Fukuoka, Japan
Federation of national public service personnel mutual aid associations Tonan Hospital, kita 1 nishi 6,Chuo-ku,Sapporo, Hokkaido, Japan
Hokkaido University Hospital, North-14 West-5 Kita-ku,Sapporo, Hokkaido, Japan
Hyogo Medical Center for Adults, 13-70,Kitaouji-cho,Akashi, Hyogo, Japan
Kobe University Graduate School of Medicine, 7-5-2,Kusunoki-cho,Chuo-ku,Kobe, Hyogo, Japan
Ibaraki Kenritsu Chuo Hospital & Cancer Center, 6528,Koibuchi,Tomobemachi,Nishi-ibarakigun, Ibaraki, Japan
Iwate Prefectural Central Hospital, 1-4-1,Ueda,Morioka, Iwate, Japan
Kanagawa Cancer Center, 1-1-2,Nakao,Asahi-ku,Yokohama, Kanagawa, Japan
Kitasato University East Hospital, 2-1-1,Asamizodai,Sagamihara, Kanagawa, Japan
Yokohama City University Medical Center, 4-57,Urafunecho,Minami-ku,Yokohama, Kanagawa, Japan
Yokohama Mucipical Citizen's Hospital, 56,Okazawa-cho,Hodogaya-ku,Yokohama, Kanagawa, Japan
Kochi Health Science Center, 2125-1,Ike,Kochi, Kochi, Japan
Kumamoto Regional Medical Center Hospital, 5-16-10,Honjo,Kumamoto, Kumamoto, Japan
Kyoto University Hospital, 54,Syogoinkawara,Sakyo-ku,Kyoto, Kyoto, Japan
Tohoku University Hospital, 1-1,Seiryo-machi,Aoba-ku,Sendai, Miyagi, Japan
Saku Central Hospital, 197,Usuda,Saku, Nagano, Japan
Osaka Medical College, 2-7,Daigakucho,Takatsuki, Osaka, Japan
Saitama Medical School Hospital, 38,Morohongo,Moroyama-machi,Iruma-gun, Saitama, Japan
Saitama Cancer Center, 818,Komuro,Ina,Kita-adachi, Saitama, Japan
Sizuoka Cancer Center, 1007,Shimonagakubo,Nagaizumi-cho,Sunto-gun, Shizuoka, Japan
Tochigi Cancer Center, 4-9-13,Yohnan,Utsunomiya, Tochigi, Japan
Showa University School of Medicine, 1-5-8,Hatanodai,Shinagawa-ku, Tokyo, Japan
Cancer Institute Hospital, 3-10-6,Ariake,Koto-ku, Tokyo, Japan
National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan
Yamagata Prefectural Central Hospital, 1800,Aoyagi,Yamagata, Yamagata, Japan
Name: Kuniaki Shirao, MD,PhD
Affiliation: Gatrointestinal Oncology Division, National Cancer Center Hospital
Role: STUDY_CHAIR