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Spots Global Cancer Trial Database for Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors

Official Title: Phase II Study of Single Agent Regorafenib in Patients With Advanced/Metastatic Neuroendocrine Tumors

Study ID: NCT02259725

Study Description

Brief Summary: This phase II trial studies regorafenib in treating patients with neuroendocrine tumors that have spread from the primary site (place where it started) to other places in the body. Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Description: PRIMARY OBJECTIVES: I. To assess progression-free survival (PFS) in advanced/metastatic in patients with carcinoid or pancreatic islet cell tumors. SECONDARY OBJECTIVES: I. To assess overall survival and response rate in advanced/metastatic poor prognosis in patients with carcinoid or pancreatic islet cell tumors. II. To assess the toxicity of patients treated with regorafenib. III. To explore markers of angiogenesis as they relate to outcome in carcinoid and pancreatic islet cell tumors. OUTLINE: Patients receive regorafenib orally (PO) once daily (QD) on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

USC Norris Comprehensive Cancer Center, Los Angeles, California, United States

Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States

USC Norris Oncology Hematology-Newport Beach, Newport Beach, California, United States

Seattle Cancer Care Alliance, Seattle, Washington, United States

Contact Details

Name: Syma Iqbal, MD

Affiliation: University of Southern California

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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