Spots Global Cancer Trial Database for Esophageal Atresia: Metaplasia, Barrett
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Trial Identification
Brief Title: Esophageal Atresia: Metaplasia, Barrett
Official Title: Prevalence of Barrett's Esophagus in Adolescents and Young Adults With Esophageal Atresia
Study ID: NCT02495051
Interventions
Study Description
Brief Summary: The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.
Detailed Description:
Eligibility
Minimum Age: 15 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Cliniques Universitaires St Luc,, Bruxelles, , Belgium
Department of Pediatric Gastroenterology, AZ VUB,, Bruxelles, , Belgium
Department of Pediatric Gastroenterology, HUDERF,, Bruxelles, , Belgium
Department of Gastroenterology CHC, Liège, Liège, , Belgium
Hôpital Mère-Enfants Ste Justine, Montréal, Canada, Montréal, , Canada
CHU Angers, Angers, , France
CHU, Bordeaux, Bordeaux, , France
CHU, Caen, Caen, , France
Centre Hospitalier, Le Havre, , France
University Hospital, Hôpital Jeanne de Flandres, Lille, , France
CHU, Lyon, Lyon, , France
CHU, Nantes, Nantes, , France
AP-HP ,Hôpital Robert Debré,, Paris, , France
AP-HP Hôpital Trousseau, Paris, , France
CHU, Poitiers, Poitiers, , France
CHU Rennes, Rennes, , France
CH Départemental Félix Guyon,, Saint Denis-La Réunion, , France
CHU, Strasbourg, Strasbourg, , France
CHU Toulouse,, Toulouse, , France
Centre Hospitalier de Luxembourg,, Luxembourg, , Luxembourg
Contact Details
Name: Frédéric Gottrand, MD, PhD
Affiliation: University Hospital, Lille
Role: STUDY_CHAIR
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