Spots Global Cancer Trial Database for Oxaliplatin - Induced Peripheral Neuropathy in Patients With Gastrointestinal Tract Cancer
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Trial Identification
Brief Title: Oxaliplatin - Induced Peripheral Neuropathy in Patients With Gastrointestinal Tract Cancer
Official Title: Relation of Genetic Polymorphism of ABCG2 Gene And Occurrence of Oxaliplatin - Induced Peripheral Neuropathy in Patients With Gastrointestinal Tract Cancer
Study ID: NCT02428101
Interventions
Study Description
Brief Summary: This study will examine DNA from Gastrointestinal Tract of cancer patients treated with oxaliplatin to look for a variation (mutation) of the ABCG2 gene that may lead to drug-induced peripheral neuropathy in certain patients. The DNA will be extracted from patients' blood samples and are analyzed for the ABCG2 single nucleotide polymorphism (G34A - rs2231137 and A/A -rs3114018 genotypes) and correlated with peripheral neuropathy grades.
Detailed Description: Pharmacogenetic analysis/genotyping : Genotyping is conducted via High Resolution Melting (HRM) TECHNIQUE, To confirm the genotyping results, the Polymerase chain reaction (PCR) product of the samples will be examine via direct sequencing using 3500 Genetic analyzer from ThermoFisher (applied biosystem) at two ABCG2 loci using the following PCR primers: 1-ABCG2 G34A - rs2231137 Forward : 5'-TGC AAT CTC ATT TAT CTG GAC TA-'3 Reverse : 5'-AAT GCC TTC AGG TCA TTG GA-'3 -Annealing temp :57 -Product size : 163 2- ABCG2 A/A - rs3114018 Forward : 5'- TGATGTTCCTTCAGCCACTG-'3 Reverse : 5'-TTGTGGAAACCTCACAAAAGTG-'3 - Annealing temp : 59 - Product size : 124
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ain Shams University hospitals, Cairo, Abbasia, Egypt
Contact Details
Name: Inas M Moukhtar Ahmed, B.pharma
Affiliation: Faculty of Pharmacy, Ain Shams Universty
Role: PRINCIPAL_INVESTIGATOR
Name: Lamia M El Wakeel, Assoc. Prof
Affiliation: Clinical Pharmacy, Ain Shams University
Role: STUDY_DIRECTOR
Name: Abdel Hady A Abdel Wahab, Professor
Affiliation: Biochemistry & Molecular biology,Cairo University
Role: STUDY_CHAIR
Name: Amr S Saad, Assoc. Prof
Affiliation: Clinical Oncology, Ain Shams University
Role: STUDY_CHAIR
Name: Raafat R Abdel-Malek, Assoc. Prof
Affiliation: clinical oncology, cairo university
Role: STUDY_CHAIR
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