Spots Global Cancer Trial Database for Genetic Investigation of Cancer Predisposition
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Trial Identification
Brief Title: Genetic Investigation of Cancer Predisposition
Official Title: Genetic Investigation of Cancer Predisposition
Study ID: NCT04620278
Interventions
Study Description
Brief Summary: Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.
Detailed Description: Genetic screening will be performed on DNA (and/or RNA) isolated from collected samples from affected individuals by whole exome sequencing or RNA sequencing using in-house pipeline to identify candidate sequence variants. These variants will be tested for segregation with the phenotype in other relatives (affected/unaffected). Candidate variants will be subjected to additional downstream analysis, to be guided by the actual type of gene/variant.
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Texas Health Science Center, San Antonio, Texas, United States
Contact Details
Name: Patricia L Dahia, MD, PhD
Affiliation: University of Texas Health at San Antonio
Role: PRINCIPAL_INVESTIGATOR
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