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Spots Global Cancer Trial Database for Low Dose Cyclophosphamide Treats Genital Warts

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Trial Identification

Brief Title: Low Dose Cyclophosphamide Treats Genital Warts

Official Title: Phase III Study of the Treatment of Genital Warts by Low Dose Cyclophosphamide

Study ID: NCT00999986

Conditions

Genital Wart

Interventions

cyclophosphamide

Study Description

Brief Summary: Condylomata acuminata (CA) caused by human papillomavirus (HPV) is a common sexually transmitted disease with half a million new cases diagnosed in the United States per year. Recurrence is a major challenge for CA treatment. The investigators have demonstrated that FOXP3+ regulatory T (Treg) cells mediate the immunosuppression in large genital warts. And low-dose cyclophosphamide (CY), a conventional chemotherapy drug, has been reported to selectively deplete Treg cells in cancer patients. Therefore, the investigators hypothesized that low-dose CY can be used to treat genital warts. In this study, 104 CA patients have been recruited for clinical trial with a 1:2 randomization. Among them, 64 patients received low-dose cyclophosphamide and 32 received placebo. In 8 extra patients, high-dose cyclophosphamide was given.

Detailed Description: Patients were first treated with CO2 laser therapy, and then treated with low-dose CY, orally 50 mg per day for 7 days.The CA recurrence were observed.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Tongji Hospital, Wuhan, Hubei, China

Contact Details

Name: Bo Huang, PH.D, MD

Affiliation: Tongji Medical College

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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