Spots Global Cancer Trial Database for Effect of stRess and exeRcize on the Outcome After Chemo-Radiation

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Effect of stRess and exeRcize on the Outcome After Chemo-Radiation

Official Title: Effect of stRess and exeRcize on the Outcome After Chemo-Radiation

Study ID: NCT05431348

Conditions

Glioblastoma (GBM)

Interventions

Smartwatch

Serum Cortisol

Questionnaires

Study Description

Brief Summary: Glioblastoma (GBM) is a highly malignant, incurable primary brain tumor. Due to the nature of this disease and the extent of the treatment (surgery followed by chemoradiation according to the Stupp trial) patients undergo considerable psychological distress. It is known that stress hormones are involved in a wide range of processes involved in cell survival, cell cycle and immune function, and can cause therapy resistance. In this study the effect of stress on outcome after chemoradiation in patients with GBM will be investigated.

Detailed Description: Psychological stress will be measured using multiple approaches; Physiological measures, stress biomarker and questionnaires. Using this approach, a broad insight in the relationship between stress and outcome after chemoradiation will be obtained and the potential influence of physical activity and sleep evaluated. In addition, the results of this study will help to identify patients which experience high stress levels during chemoradiation to pilot (in the future) interventions to reduce stress before and during treatment.