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Brief Title: The Effects of NVX-108 as a Radiation Sensitizer in Glioblastoma
Official Title: A Phase 1b Dose-finding, Pharmacokinetic and Pharmacodynamic Study of NVX-108 Combined With Radiation and Temozolomide in Patients With Newly-diagnosed Glioblastoma Multiforme
Study ID: NCT02189109
Brief Summary: This clinical trial is testing the safety, tolerability and effectiveness of NVX-108 administered via intravenous infusion in combination with standard radiation and chemotherapy. NVX-108 is being developed to increase the amount of oxygen delivered to tumors which is hoped to increase the effectiveness of radiation therapy.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
St. Vincents Hospital Sydney, Darlinghurst, New South Wales, Australia
Flinders Medical Centre, Adelaide, South Australia, Australia
Nucleus Network, Melbourne, Victoria, Australia
Epworth Center, Melbourne, Victoria, Australia
Name: Jason Lickliter, MBBSPhDFRACP
Affiliation: Nucleus Network
Role: PRINCIPAL_INVESTIGATOR