Spots Global Cancer Trial Database for A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
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Trial Identification
Brief Title: A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
Official Title: A Randomised Phase 2 Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
Study ID: NCT01602588
Conditions
Study Description
Brief Summary: There is emerging evidence that hydroxychloroquine (HCQ), a drug used commonly in the prevention/ treatment of malaria, rheumatoid arthritis and lupus erythematosus, may improve survival outcome in a variety of cancers including HGG, with few side effects. In this trial the investigators wish to investigate whether treatment with radiotherapy and hydroxychloroquine is more effective than treatment with radiotherapy alone.
Detailed Description:
Keywords
Eligibility
Minimum Age: 70 Years
Eligible Ages: OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
St James's University Hospital, Leeds, West Yorkshire, United Kingdom
Glan Clwyd Hospital, Bodelwyddan, , United Kingdom
Addenbrooke's Hospital, Cambridge, , United Kingdom
Ninewells Hospital, Dundee, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Royal Surrey County Hospital, Guildford, , United Kingdom
University College Hospital, London, , United Kingdom
Guy's and St Thomas's Hospitals, London, , United Kingdom
Charing Cross Hospital, London, , United Kingdom
Christie Hospital, Manchester, , United Kingdom
James Cook University Hospital, Middlesbrough, , United Kingdom
Freeman Hospital, Newcastle, , United Kingdom
Norfolk & Norwich University Hospitals, Norwich, , United Kingdom
The Royal Preston Hospital, Preston, , United Kingdom
Royal Stoke University Hospital, Stoke-on-Trent, , United Kingdom
Contact Details
Name: Susan Short, Professor
Affiliation: St James's University Hospital
Role: PRINCIPAL_INVESTIGATOR
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