Spots Global Cancer Trial Database for Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

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Trial Identification

Brief Title: Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

Official Title: 4π Radiotherapy for Recurrent Glioblastoma Multiforme: A Feasibility Trial

Study ID: NCT02575027

Conditions

Glioblastoma

Recurrent Brain Neoplasm

Interventions

Palliative Radiation Therapy

Questionnaire Administration

Radiation Therapy Treatment Planning and Simulation

Study Description

Brief Summary: This pilot clinical trial studies the feasibility of palliative 4pi radiotherapy in treating patients with glioblastoma multiforme that has come back after standard chemoradiation. A new radiotherapy delivery planning system, called 4pi radiotherapy, may help improve radiation delivery by improving dose coverage to the treatment target, while reducing the dose to surrounding normal tissues.

Detailed Description: PRIMARY OBJECTIVES: I. To determine the accuracy of dose delivery and patient comfort with treatment time. II. To evaluate normal tissue dose volume statistics and compare to standard planning. OUTLINE: Patients undergo 4pi radiation simulation and planning followed by 5 to 10 daily fractions of 4pi palliative radiotherapy. If an acceptable plan cannot be achieved using 4pi planning, then the patient will be treated with standard radiation therapy planning for palliative re-irradiation. After completion of study treatment, patients are followed up at 6 weeks.