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Brief Title: A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma
Official Title: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Safety and Efficacy of IGV-001, an Autologous Cell Immunotherapy With Antisense Oligonucleotide (IMV-001) Targeting IGF-1R, in Newly Diagnosed Patients With Glioblastoma
Study ID: NCT04485949
Brief Summary: The purpose of this study is to assess progression-free survival (PFS) and overall survival (OS) in newly diagnosed Glioblastoma (GBM) participants treated with IGV-001 as compared with placebo.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
Tufts Medical Center, Boston, Massachusetts, United States
Henry Ford Health System, Detroit, Michigan, United States
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States
John Theurer Cancer Center At Hackensack UMC, Hackensack, New Jersey, United States
Jersey Shore University Medical Center, Neptune, New Jersey, United States
Montefiore Medical Center, Bronx, New York, United States
Northwell Health at North Shore University Hospital, Manhasset, New York, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York, New York, United States
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Columbia University Medical Center, New York, New York, United States
Weill Cornell Medicine, New York, New York, United States
Lenox Hill Hospital, New York, New York, United States
Westchester Medical Center, Valhalla, New York, United States
University of North Carolina (UNC) - Chapel Hill, Chapel Hill, North Carolina, United States
UC Health, Cincinnati, Ohio, United States
The Ohio State University (OSU) Wexner Medical Center, Columbus, Ohio, United States
The Pennsylvania State University (Penn State) Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Rhode Island Hospital, Providence, Rhode Island, United States
West Virginia University, Morgantown, West Virginia, United States
University of Wisconsin - Madison, Madison, Wisconsin, United States