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Brief Title: A Phase 3, Pivotal Trial of VB-111 Plus Bevacizumab vs. Bevacizumab in Patients With Recurrent Glioblastoma (GLOBE)
Official Title: A Phase 3, Randomized, Controlled, Double-Arm, Open-Label, Multi-center Study of VB-111 Combined With Bevacizumab vs. Bevacizumab Monotherapy in Patients With Recurrent Glioblastoma
Study ID: NCT02511405
Brief Summary: The purpose of this pivotal, phase 3, randomized, multicenter study is to compare VB-111 plus bevacizumab to bevacizumab in adult patients with recurrent Glioblastoma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Alabama, Birmingham, Alabama, United States
Highlands Oncology Group, Rogers, Arizona, United States
University of California Irvine Medical Center, Irvine, California, United States
University of California Los Angeles, Los Angeles, California, United States
The Center for Cancer Prevention and Treatment, Orangevale, California, United States
Kaiser Permanente - Redwood City Medical Center, Redwood City, California, United States
University of California, San Diego, California, United States
University of California San Francisco, San Francisco, California, United States
Stanford University, Stanford, California, United States
Colorado Neurological Institute, Denver, Colorado, United States
The George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
University of Florida Preston A. Wells, Jr. Center for Brain Tumor Therapy, Gainesville, Florida, United States
Orlando Health, Orlando, Florida, United States
Piedmont Physicians Neuro-Oncology, Atlanta, Georgia, United States
Northwestern University, Chicago, Illinois, United States
The University of Chicago, Chicago, Illinois, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
University of Kentucky, Lexington, Kentucky, United States
University of Louisville, Louisville, Kentucky, United States
Louisiana State University Health Science Center, Shreveport, Louisiana, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Henry Ford Health System, Detroit, Michigan, United States
Metro-MN Community Oncology Research Consortium, Minneapolis, Minnesota, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States
Dent Neurosciences Research Center, Amherst, New York, United States
North Shore University Hospital, Lake Success, New York, United States
Columbia University Medical Center, New York, New York, United States
Derald H. Ruttenberg Treatment Center, New York, New York, United States
University of Rochester Medical Center, Rochester, New York, United States
Stony Brook University, Neurology Associates of Stony Brook, Stony Brook, New York, United States
SUNY Upstate Medical University, Syracuse, New York, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Texas Oncology-Austin Midtown, Austin, Texas, United States
Baylor Health Neuro-Oncology Associates, Dallas, Texas, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
: University of Texas, HSC, Houston, Texas, United States
MD Anderson, Houston, Texas, United States
UTHSCSA, San Antonio, Texas, United States
Huntsman Cancer Institute at The University of Utah, Salt Lake City, Utah, United States
University of Virginia, Charlottesville, Virginia, United States
Swedish Medical Center, Seattle, Washington, United States
University of Wisconsin, Madison, Wisconsin, United States
Tom Baker Cancer Centre, Calgary, Alberta, Canada
London Health Sciences Centre, London, Ontario, Canada
Ottawa Hospital, Ottawa, Ontario, Canada
Sunnybrook Health Science Centre, Toronto, Ontario, Canada
Rambam Medical Center, Haifa, , Israel
Hadassah Medical Center, Jerusalem, , Israel
Rabin Medical Center, Petach Tikvah, , Israel
Chaim Sheba Medical Center, Ramat Gan, , Israel
Tel Aviv Sourasky Medical Center, Tel Aviv, , Israel