⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for Azeliragon in MGMT Unmethylated Glioblastoma

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Azeliragon in MGMT Unmethylated Glioblastoma

Official Title: A Phase II Study to Assess Safety and Preliminary Evidence of a Therapeutic Effect of Azeliragon in Patients With MGMT Unmethylated Glioblastoma

Study ID: NCT05986851

Conditions

Glioblastoma

Interventions

Azeliragon

Study Description

Brief Summary: This is a phase 2 study to evaluate the safety and preliminary evidence of effectiveness of azeliragon, in combination with radiation therapy, as an initial treatment of a form of glioblastoma. Glioblastoma is a type of brain cancer that grows quickly and can invade and destroy healthy tissue. There's no cure for glioblastoma, which is also known as glioblastoma multiforme. Treatments, including surgery, radiation, and chemotherapy might slow cancer growth and reduce symptoms. New treatments of glioblastoma are needed.

Detailed Description: The study to be conducted is a phase 2 study in newly diagnosed "unmethylated" glioblastoma. As compared to "methylated" glioblastoma "unmethylated" glioblastoma carries a worse prognosis, as it is resistant to temozolomide, the most commonly prescribed chemotherapeutic treatment. Based upon pre-clinical evidence suggesting that azeliragon may enhance the effectiveness of radiation, as well as have a delaying effect on disease progression, this study will combine daily oral azeliragon with radiation treatment, followed by continued administration of azeliragon after completion of radiation therapy. Azeliragon is administered once daily as an oral capsule. In previous studies in patients with Alzheimer's disease and in normal volunteers, azeliragon was well tolerated for up to 18 months.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Miami Cancer Institute - Baptist Health, Miami, Florida, United States

Corewell Health, Royal Oak, Michigan, United States

Washington University in St. Louis, Saint Louis, Missouri, United States

Lenox Hill Hospital, New York, New York, United States

The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States

University of Utah Health Huntsman Cancer Center, Salt Lake City, Utah, United States

University of Washington, Seattle, Washington, United States

Contact Details

Name: Stephen G Marcus, MD

Affiliation: Cantex Pharmaceuticals

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: