Spots Global Cancer Trial Database for A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer
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Trial Identification
Brief Title: A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer
Official Title: A Phase IB Combination Study of Rucaparib (CO-338) and Atezolizumab (MPDL3280A) in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer
Study ID: NCT03101280
Conditions
Study Description
Brief Summary: This is a Phase Ib, open-label, non-randomized study in patients with previously treated advanced ovarian or endometrial cancer (Part 1) and platinum-sensitive ovarian cancer or triple-negative breast cancer (TNBC) (Part 2) to investigate the dose, safety, pharmacokinetics, and preliminary efficacy of rucaparib in combination with atezolizumab. The study is conducted in 2 parts: a Dose-Finding Phase (Part 1) and a Dose-Expansion Phase (Part 2)
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
Centre Leon Berard, Lyon, , France
Centre Hospitalier Lyon Sud; Service d'Oncologie Médicale, Pierre Benite, , France
Gustave Roussy, Villejuif CEDEX, , France
Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Hospital Universitario Vall d'Hebron, Barcelona, , Spain
La Paz University Hospital, Madrid, , Spain
Royal Marsden Hospital - London, London, , United Kingdom
University College London Hospitals NHS Foundation Trust - University College Hospital, London, , United Kingdom
Lancashire Teaching Hospitals NHS Foundation Trust, Preston, , United Kingdom
Royal Marsden NHS Foundation Trust, Sutton, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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